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Scuola di Dottorato

Dottorato in Fisiopatologia Medica

Logo di Dottorato in Fisiopatologia Medica

Fabrizio Buffolo

Tesi di dottorato

Study on miRNA expression in urinary extracellular vesicles of patients under modulation of sodium intake

Attività di ricerca

2023

  1. Circulating extracellular vesicles derived from tumor endothelial cells hijack the local and systemic anti-tumor immune response: Role of mTOR/G-CSF pathway.
    Koni M, Lopatina T, Grange C, Sarcinella A, Cedrino M, Bruno S, Buffolo F, Femminò S, Camussi G, Brizzi MF.Pharmacol Res. 2023 Sep;195:106871. doi: 10.1016/j.phrs.2023.106871. Epub 2023 Jul 26.
  2. Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.
    Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E.Circulation. 2023 Aug 22;148(8):661-678. doi: 10.1161/CIRCULATIONAHA.122.063402. Epub 2023 Jul 10.
  3. Prevalence of Cortisol Cosecretion in Patients With Primary Aldosteronism: Role of Metanephrine in Adrenal Vein Sampling.
    Buffolo F, Pieroni J, Ponzetto F, Forestiero V, Rossato D, Fonio P, Nonnato A, Settanni F, Mulatero P, Mengozzi G, Monticone S.J Clin Endocrinol Metab. 2023 Aug 18;108(9):e720-e725. doi: 10.1210/clinem/dgad179.

2022

  1. Aldosterone as a Mediator of Cardiovascular Damage. Buffolo F, Tetti M, Mulatero P, Monticone S.Hypertension. 2022 Sep;79(9):1899-1911. doi: 10.1161/HYPERTENSIONAHA.122.17964
  2. Role of Extracellular Vesicles in the Pathogenesis of Vascular Damage. Buffolo F, Monticone S, Camussi G, Aikawa E.Hypertension. 2022 May;79(5):863-873. doi: 10.1161/HYPERTENSIONAHA.121.17957
  3. Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial.
    Manzini PM, Ciccone G, De Rosa FG, Cavallo R, Ghisetti V, D'Antico S, Galassi C, Saccona F, Castiglione A, Birocco N, Francisci T, Hu H, Pecoraro C, Danielle F, Labanca L, Bordiga AM, Lorenzi M, Camisasca G, Giachino O, Pagliarino M, Ottone P, Scuvera ITD, Guaschino R, Freilone R, Berti P, Pittaluga F, Avolio M, Costa C, Raso S, Nucci A, Milan M, Baffa A, Russo A, Tornello A, Maddalena L, Delios G, Marletto FP, De Micheli AG, Mattei A, Baldassano S, Canta F, Russo ML, Bergamo D, Vitale F, Liccardi MM, Chinaglia A, Calcagno A, Converso M, Aldieri C, Libanore V, Blangetti I, Benedetti V, Mitola B, Scozzari G; PLACO COVID Study Group.

2021

  1. Clinical Score and Machine Learning-Based Model to Predict Diagnosis of Primary Aldosteronism in Arterial Hypertension. Buffolo F, Burrello J, Burrello A, Heinrich D, Adolf C, Müller LM, Chen R, Forestiero V, Sconfienza E, Tetti M, Veglio F, Williams TA, Mulatero P, Monticone S. Hypertension. 2021 Sep 7:HYPERTENSIONAHA12117444. doi: 10.1161/HYPERTENSIONAHA.121.17444.
  2. Assessment of Anti-Hypertensive Drug Adherence by Serial Aldosterone-To-Renin Ratio Measurement.Buffolo F, Sconfienza E, Burrello J, Losano I, Mengozzi G, Priolo G, Avataneo V, D'Avolio A, Veglio F, Rabbia F, Mulatero P, Monticone S.Front Pharmacol. 2021 May 10;12:668843. doi: 10.3389/fphar.2021.668843. eCollection 2021.
  3. Mineralocorticoid Receptor Antagonist Effect on Aldosterone to Renin Ratio in Patients With Primary Aldosteronism. Pecori A*, Buffolo F*, Burrello J, Mengozzi G, Rumbolo F, Avataneo V, D'Avolio A, Rabbia F, Bertello C, Veglio F, Mulatero P, Monticone S. J Clin Endocrinol Metab. 2021 Aug 18;106(9):e3655-e3664. doi: 10.1210/clinem/dgab290. [*Joint First Authorship]
  4. Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model. Ruiz JL, Hutcheson JD, Cardoso L, Bakhshian Nik A, Condado de Abreu A, Pham T, Buffolo F, Busatto S, Federici S, Ridolfi A, Aikawa M, Bertazzo S, Bergese P, Weinbaum S, Aikawa E. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e1811725118. doi: 10.1073/pnas.1811725118. 
  5. Development of a Prediction Score to Avoid Confirmatory Testing in Patients With Suspected Primary Aldosteronism. Burrello J, Amongero M, Buffolo F, Sconfienza E, Forestiero V, Burrello A, Adolf C, Handgriff L, Reincke M, Veglio F, Williams TA, Monticone S, Mulatero P. J Clin Endocrinol Metab. 2021 Mar 25;106(4):e1708-e1716. doi: 10.1210/clinem/dgaa974.
  6. Quality of life in primary aldosteronism: A prospective observational study. Buffolo F, Cavaglià G, Burrello J, Amongero M, Tetti M, Pecori A, Sconfienza E, Veglio F, Mulatero P, Monticone S. Eur J Clin Invest. 2021 Mar;51(3):e13419. doi: 10.1111/eci.13419.

2020

  1. Use of Steroid Profiling Combined With Machine Learning for Identification and Subtype Classification in Primary Aldosteronism. Eisenhofer G, Durán C, Cannistraci CV, Peitzsch M, Williams TA, Riester A, Burrello J, Buffolo F, Prejbisz A, Beuschlein F, Januszewicz A, Mulatero P, Lenders JWM, Reincke M. JAMA Netw Open. 2020 Sep 1;3(9):e2016209. doi: 10.1001/jamanetworkopen.2020.16209.
  2. Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis. Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E. Sci Adv. 2020 Sep 16;6(38):eabb1244. doi: 10.1126/sciadv.abb1244. Print 2020 Sep.
  3. Primary Aldosteronism and Obstructive Sleep Apnea: Casual Association or Pathophysiological Link? Pecori A, Buffolo F, Pieroni J, Forestiero V, Sconfienza E, Veglio F, Mulatero P, Monticone S. Horm Metab Res. 2020 Jun;52(6):366-372. doi: 10.1055/a-1133-7255.
  4. The spectrum of low-renin hypertension. Buffolo F, Monticone S, Pecori A, Pieroni J, Losano I, Cavaglià G, Tetti M, Veglio F, Mulatero P. Best Pract Res Clin Endocrinol Metab. 2020 Feb 25:101399. doi: 10.1016/j.beem.2020.101399.
  5. Chest swelling in a patient from West Africa. Elia F, Buffolo F, Aprà F. Intern Emerg Med. 2020 Mar 6. doi: 10.1007/s11739-020-02296-1.
  6. Prevalence of Hypokalemia and Primary Aldosteronism in 5100 Patients Referred to a Tertiary Hypertension Unit. Burrello J, Monticone S, Losano I, Cavaglià G, Buffolo F, Tetti M, Covella M, Rabbia F, Veglio F, Pasini B, Williams TA, Mulatero P. Hypertension. 2020 Apr;75(4):1025-1033. doi: 10.1161/HYPERTENSIONAHA.119.14063.
  7. Renin-Angiotensin-Aldosterone System Triple-A Analysis for the Screening of Primary Aldosteronism. Burrello J, Buffolo F, Domenig O, Tetti M, Pecori A, Monticone S, Poglitsch M, Mulatero P. Hypertension. 2020 Jan;75(1):163-172. doi: 10.1161/HYPERTENSIONAHA.119.13772.
  8. Renal damage in primary aldosteronism: a systematic review and meta-analysis. Monticone S, Sconfienza E, D'Ascenzo F, Buffolo F, Satoh F, Sechi LA, Veglio F, Mulatero P. J Hypertens. 2020 Jan;38(1):3-12. doi: 10.1097/HJH.0000000000002216.

2019

  1. Primary Aldosteronism and Obstructive Sleep Apnea: A Cross-Sectional Multi-Ethnic Study. Buffolo F, Li Q, Monticone S, Heinrich DA, Mattei A, Pieroni J, Mei M, Yang S, Hu YH, Yang MC, Sabbadin C, Pizzolo F, Giacchetti G, Fallo F, Veglio F, Reincke M, Wu VC, Mulatero P. Hypertension. 2019 Dec;74(6):1532-1540. doi: 10.1161/HYPERTENSIONAHA.119.13833.

2018

  1. PDGF enhances the protective effect of adipose stem cell-derived extracellular vesicles in a model of acute hindlimb ischemia. Lopatina T, Favaro E, Grange C, Cedrino M, Ranghino A, Occhipinti S, Fallo S, Buffolo F, Gaykalova DA, Zanone MM, Romagnoli R, Camussi G. Sci Rep. 2018 Dec 4;8(1):17458. doi: 10.1038/s41598-018-36143-3.
  2. Diagnostic approach to low-renin hypertension. Monticone S, Losano I, Tetti M, Buffolo F, Veglio F, Mulatero P. Clin Endocrinol (Oxf). 2018 Oct;89(4):385-396. doi: 10.1111/cen.13741. Epub 2018 Jun 6. Review.
  3. Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E. Nanomaterials. 2018 May 3;8(5). pii: E296. doi: 10.3390/nano8050296.
  4. Primary aldosteronism in the primary care setting. Buffolo F, Monticone S, Tetti M, Mulatero P. Curr Opin Endocrinol Diabetes Obes. 2018 Jun;25(3):155-159. doi: 10.1097/MED.0000000000000408.
  5. GENETICS IN ENDOCRINOLOGY: The expanding genetic horizon of primary aldosteronism. Monticone S, Buffolo F, Tetti M, Veglio F, Pasini B, Mulatero P.Eur J Endocrinol. 2018 Mar;178(3):R101-R111. doi: 10.1530/EJE-17-0946. Epub 2018 Jan 18.

2017

  1. A Case of Adrenal Vein Sampling in Primary Aldosteronism With Homolateral Suppression. Viola A, Monticone S, Rossato D, Versace K, Castellano I, Burrello J, Buffolo F, Veglio F, Mulatero P. J Endocr Soc. 2017 Mar 17;1(5):401-406. doi: 10.1210/js.2016-1105. eCollection 2017 May 1.
  2. Is Primary Aldosteronism Still Largely Unrecognized? Buffolo F, Monticone S, Burrello J, Tetti M, Veglio F, Williams TA, Mulatero P. Horm Metab Res. 2017 Dec;49(12):908-914. doi: 10.1055/s-0043-119755. Epub 2017 Nov 16.
  3. Is There a Role for Genomics in the Management of Hypertension? Burrello J, Monticone S, Buffolo F, Tetti M, Veglio F, Williams TA, Mulatero P. Int J Mol Sci. 2017 May 26;18(6). pii: E1131. doi: 10.3390/ijms18061131.
  4. Familial hyperaldosteronism type III. Monticone S, Tetti M, Burrello J, Buffolo F, De Giovanni R, Veglio F, Williams TA, Mulatero P. J Hum Hypertens. 2017 Dec;31(12):776-781. doi: 10.1038/jhh.2017.34. Epub 2017 Apr 27.
  5. Subtype Diagnosis of Primary Aldosteronism: Is Adrenal Vein Sampling Always Necessary? Buffolo F, Monticone S, Williams TA, Rossato D, Burrello J, Tetti M, Veglio F, Mulatero P. Int J Mol Sci. 2017 Apr 17;18(4). pii: E848. doi: 10.3390/ijms18040848.
  6. Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice. Monticone S, Burrello J, Tizzani D, Bertello C, Viola A, Buffolo F, Gabetti L, Mengozzi G, Williams TA, Rabbia F, Veglio F, Mulatero P. J Am Coll Cardiol. 2017 Apr 11;69(14):1811-1820. doi: 10.1016/j.jacc.2017.01.052.

2016

  1. Hyperaldosteronism: How to Discriminate Among Different Disease Forms? Crudo V, Monticone S, Burrello J, Buffolo F, Tetti M, Veglio F, Mulatero P. High Blood Press Cardiovasc Prev. 2016 Sep;23(3):203-8. doi: 10.1007/s40292-016-0151-6. Epub 2016 May 2.
  2. Diagnostic accuracy of aldosterone and renin measurement by chemiluminescent immunoassay and radioimmunoassay in primary aldosteronism. Burrello J, Monticone S, Buffolo F, Lucchiari M, Tetti M, Rabbia F, Mengozzi G, Williams TA, Veglio F, Mulatero P. J Hypertens. 2016 May;34(5):920-7. doi: 10.1097/HJH.0000000000000880.
  3. Issues in the Diagnosis and Treatment of Primary Aldosteronism. Burrello J, Monticone S, Buffolo F, Tetti M, Giraudo G, Schiavone D, Veglio F, Mulatero P. High Blood Press Cardiovasc Prev. 2016 Jun;23(2):73-82. doi: 10.1007/s40292-015-0084-5. Epub 2015 Apr 9.

2015

  1. Renin and aldosterone measurements in the management of arterial hypertension. Viola A, Monticone S, Burrello J, Buffolo F, Lucchiari M, Rabbia F, Williams TA, Veglio F, Mengozzi G, Mulatero P. Horm Metab Res. 2015 Jun;47(6):418-26. doi: 10.1055/s-0035-1548868. Epub 2015 May 8.

2014

  1. Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas. Williams TA, Monticone S, Schack VR, Stindl J, Burrello J, Buffolo F, Annaratone L, Castellano I, Beuschlein F, Reincke M, Lucatello B, Ronconi V, Fallo F, Bernini G, Maccario M, Giacchetti G, Veglio F, Warth R, Vilsen B, Mulatero P. Hypertension. 2014 Jan;63(1):188-95. doi: 10.1161/HYPERTENSIONAHA.113.01733. Epub 2013 Sep 30.

2013

  1. Effectiveness of blood pressure educational and evaluation program for the improvement of measurement accuracy among nurses. Rabbia F, Testa E, Rabbia S, Praticò S, Colasanto C, Montersino F, Berra E, Covella M, Fulcheri C, Di Monaco S, Buffolo F, Totaro S, Veglio F. High Blood Press Cardiovasc Prev. 2013 Jun;20(2):77-80. doi: 10.1007/s40292-013-0012-5. Epub 2013 May 8.

 

2023

1. XV Giornate Piemontesi dei Giovani Internisti (Invited Speaker: "Assessment of anti-hypertensive drug adherence by serial aldosterone-to-renin ratio measurement")

2. EVIta 2023 (Poster presentation:"Small-RNA sequencing of human urinary extracellular vesicles reveals renal pro-inflammatory role of high sodium diet")

3. XL Congresso Nazionale SIIA 2023 (Oral presentation:"Effects of cosyntropin stimulation in Adrenal Venous Sampling in Primary Aldosteronism")

4. XL Congresso Nazionale SIIA 2023 (Poster presentation:"Prevalence of asymmetrical cortisol secretion in primary aldosteronism and use of metanephrine normalization in adrenal venous sampling")

2022

1.  XXXIX Congresso nazionale della società italiana dell'ipertensione arteriosa (Poster Presentation:"Development of a clinical score and machine learning-based models to predict primary aldosteronism in patients with arterial hypertension")

2. 31st ESH European Meeting on Hypertension and Cardiovascular Protection (Oral Presentation:"Development of clinical scoring system and machine learning-based model to predict diagnosis of primary aldosteronism in patients with arterial hypertension"; and Poster Presentation:"Estimate of anti-hypertensive drug adherence through serial measurments of aldosterone-to-renin ratio")

2021

1. Joint Meeting ESH-ISH On-Air - April 11-14, 2021 (Oral Presentation: "Obstructive Sleep Apnea and Primary AldosteronismA multicenter cross-sectional study")

2.  SPRING Young Investigators Meeting SIIA-SIMI-SIPREC-SISA Virtual Edition (Poster "Quality of life in primary aldosteronism")

3. XXXVIII National Congress of the Italian Society of Hypertension (Abstract "Serial measurement of aldosterone-to-renin ratio for the assessment of anti-hypertensive drug adherence" and "Quality of life in primary aldosteronism before and after treatment: a prospective observational study")

4. 2nd EVIta Symposium (Attendance)

2020

1. XXXVII National Congress of the Italian Society of Hypertension - Digital edition (Abstract:"Iperaldosteronismo primitivo e apnee ostruttive notturne: uno studio multi-centrico e multi-etnico) 

2019

1. Progress in Primary Aldosteronism 6 – Munich, Germany (Oral  Presentation:“Obstructive Sleep Apnea and Primary Aldosteronism: a multicenter cross-sectional study”)

2. Congresso interregionale SIIA – Piemonte Liguria e Valle d’Aosta – Torino 2019 (Oral Presentation: “Iperaldosteronismo primitivo ed sindrome delle apnee notturne: associazione non casuale”)

3. SPRING Young Investigators Meeting SIIA-SIMI-SISA – Rimini (Oral Presentation: ”Revisione sistematica e metanalisi del danno d’organo renale nell’iperaldosteronismo primitivo”)

4. A.R.C.A. Young Investigator Awards Meeting (Oral Presentation:"Caratterizzazione di extracellular vesicles isolate da tessuto valvolare aortico e da placca aterosclerotica carotidea")

2017.

1. X Giornate Piemontesi dei Giovani Internisti -  Torino (Oral Presentation:“Paziente iperteso: pensiamo all’iperaldosteronismo”)

2. XXXIV National Congress of the Italian Society of Hypertension (Poster:"Un caso di cateterismo venoso surrenalico in iperaldosteronismo primitivo con soppressione omolaterale")

2016

1. Congresso interregionale SIIA – Piemonte Liguria e Valle d’Aosta – Torino (Oral Presentation:“Ipertensione e ipoaldosteronismo iporeninemico”)

1. Premio “Alberto ZanchettI 2023” per la miglior pubblicazione scientifica istituito dalla Società Italiana di Ipertensione Arteriosa

2.  2nd position in the the 60-MCQ test of ESH Summer school 2019

3.  Bests Oral Presentations - Spring Meeting Giovani Ricercatori SIIA, SIMI, SISA - 2019

Società Italiana di Ipertensione Arteriosa (SIIA)
Società Italiana per le Vescicole Extracellulari (EVITA)

Frontiers in Cardiovascular Medicine (Since 20/05/2020 – ongoing) as Review Editor in Heart Valve Disease

Langebeck`s Arichive of Surgery; Journal of Extracellular Vesicles; Endocrinology, Diabetes & Metabolism Case Report; Endocrine Connections; Hormone and Metabolic Research; International Journal of Endocrinology; Journal Endocrinological Investigation; Journal of Human Hypertension; Journal of Hypertension; Pharmacogenomics; Endocrine; Frontiers in Endocrinology; American Journal of Medicine; Hypertension; Acta Diabetologica; Clinical
Epigenetics; Journal of Diabetes Research; PLoS One; Therapeutics advances in Endocrinology and Metabolism; Frontiers in Oncology; International Immunopharmacology

  1. 29 July 2021, University of Torino: Fitting regression models: interpretation of regression coefficients, uncertainty measures and hypothesis testing - Milena Maule
  2. 30 August 2021, University of Torino: Physiopathology of diabetic nephropathy - Gabriella Gruden
  3. 31 August 2021, University of Torino: Update on physiology of hypertension - Franco Veglio
  4. 6 September 2021, University of Torino: Precision medicine in oncology: Putting drivers and targets in context - Livio Trusolino
  5. 8 September 2021, University of Torino: How to write a scientific paper - Riccarda Granata
  6. 13 September 2021, University of Torino: Targets for functional imaging in medicine - Desireè Deandreis:
  7. 15 Semptember 2021, University of Torino: Scientific presentations - Benedetta Bussolati
  8. 23 September 2021, University of Torino: Regression models: from the linear model to the generalised linear models. Interpretation of interactions between predictors - Milena Maule
  9. 28 September 2021, University of Torino: Etiopathogenesis of diabetic retinopathy - Massimo Porta
  10. 14 June 2022, University of Torino: Monogenic forms of hypertension - Paolo Mulatero
  11. 1 September 2022, University of Torino: Diabetic nephropathy - Gabriella Gruden/Federica Barutta
  12. 13 September 2022, University of Torino: Precision medicine in oncology: putting drivers targets in context - Livio Trusolino
  13. 20 September 2022, University of Torino: Cancer survivors: pathophysiology of late-effects and challenges in their management - Emanuela Arvat
  14. 1 June 2023, University of Torino: Alteration of intestinal microbioma as organ insufficiency: practical implications - Francesco Giuseppe De Rosa
  15. 6 June 2023, University of Torino: Biology and Diagnosis of SARS CoV2 - Cristina Costa
  16. 8 June 2023, University of Torino: Cardiac electric physiopathological properties - Gaetano De Ferrari
  17. 8 June 2023, University of Torino: Therapeutic strategies for liver transplant - Renato Romagnoli
Ultimo aggiornamento: 05/10/2023 10:49
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