Dottorato in Fisiopatologia Medica

Contatti

Attività di ricerca

PROJECT

“Artificial intelligence and machine learning applications in Nuclear Medicine for the identification of predictive and prognostic factors in oncological and endocrinological diseases”

 

ATTENDED PhD COURSES & OTHER TRAINING

A.A. 2022/2023

PhD Classes

June 13, 2023 - Cancer survivors: pathophysiology of late-effects and challenges in their management - Prof.ssa Arvat

June 29, 2023 - Diabetic nephropathy – Prof.ssa Gruden

September 5, 2023 - Extracellular vesicles and liquid biopsy - Prof.ssa Bussolati 

September 7, 2023 - Impact of the metabolic syndrome on the digestive tract - Prof.ssa Bugianesi

 

UniTo Statistics Course

March 6-9-10, 2023 - Statistica di base

March 7-8, 2023 - Inferenza causale in epidemiologia clinica

March 15-16, 2023 - Disegno dello studio e misure epidemiologiche

March 23, 2023 - La dimensione campionaria

April 13-14, 2023 - Ricerca in campo diagnostico

 

E-learning courses

• La radioprotezione ai sensi del D.Lgs. 101/2020 per medici e odontoiatri (4 Dec 2022, 8h)

FNOMCeO FAD course (ECM 353910, provider code 2603) - 8 ECM credits

• Sicurezza e interventi di emergenza negli ambienti di lavoro (24 Dec 2022, 12h)

FNOMCeO FAD course (ECM 351069, provider code 2603) - 12 ECM credits

• Finding Funding Opportunities (19 Oct 2023, 3.5 h)

Nature Masterclasses Online Course

 

Research Experience Abroad

• 05/05/2023 - 20/05/2023 Nuclear Medicine Internship and Research training

Institute Gustave Roussy, Villejuif, France

 

Attended Scientific Events

• “Introduction to Radiomics for Nuclear Medicine”

Online webinar AIMN, 16 Jan 2023, 2h

• “AIRC calls for Individual Grant 2023”

Online webinar AIRC, 08 Feb 2023, 1.5 h

• “Online Guidance for PhD Candidates”

Online webinar UniTo, 21 Feb 2023, 2h

• “Opportunità per le imprese – Dottorati e Industria”

Grugliasco, 22 Feb 2023, 2.5h

• “L’impatto della ricerca sul mercato del lavoro”

Online webinar UniTo, 23 Feb 2023, 1h

• “Progetti Terza Missione per la disseminazione e la divulgazione della ricerca”

UniTo, 2 Mar 2023, 1h

• “UNITA Days – European UNITA Alliance”

Torino – Campus Luigi Einaudi, 13 Mar 2023, 1.5h

• “How to value artificial intelligence in Nuclear Medicine”

Online webinar EANM/ESMIT, 24 Mar 2023, 1h

• “New York Career Day 2023: Opportunities for Italian Researchers”

Online Webinar AIRIcerca, 29 Mar 2023, 2.5h

• “Dosimetry across the water”

Online webinar EANM/ESMIT, 14 Apr 2023, 1.5h

• “XXVII corso nazionale di aggiornamento in medicina nucleare e imaging molecolare”

Catania, 12-15 May 2023

• “My 3-minute PhD thesis" - European UNITA alliance

Turin, 28 Jun 2023

• “36^th Annual Congress of the European Association of Nuclear Medicine”

Vienna, 9 - 13 Sept 2023

• AIMN Course - “Metodologia della Ricerca e Pubblicazione Scientifica”

Milan, 20 Oct 2023

 

A.A. 2021/2022

Approaches to scientific research (22 hours)

June 28, 2022 - Precision medicine in oncology: putting drivers and targets in context – Prof. Livio Trusolino

June 30, 2022 - How to write a scientific paper – Prof.ssa Riccarda Granata

July 07, 2022 - How to set up an in vivo experimental model – Prof.ssa Stefania Bruno

July 12, 2022 - Fitting regression models: interpretation of regression coefficients, uncertainty measures and hypothesis testing - Prof.ssa Milena Maule

July 19, 2022 - Regression models: from the linear model to the generalised linear models. Interpretation of interactions between predictors - Prof.ssa Milena Maule

September 27, 2022 - Scientific presentations – Prof.ssa Benedetta Bussolati

Pathophysiological basis of diseases (20 hours)

July 05, 2022 - Update on physiology of hypertension – Prof. Franco Veglio

June 21, 2022 - Etiopathogenesis of diabetic retinopathy – Prof. Massimo Porta

September 6, 2022 - Physiopathology of diabetic nephropathy – Prof.ssa Gabriella Gruden

September 8, 2022 - Targets for functional imaging in medicine – Prof.ssa Désirée Deandreis

September 15, 2022 - Physiopathology of autoimmune hepatitis – Prof.ssa Marilena Durazzo *Rescheduled

E-learning courses

05-06/10/2022 – Nature Masterclasses: Managing Research Data (5h) - Link: https://masterclasses.nature.com/managing-research-data/18320206

01/06/2022 – 23/09/2022 Bibliography and bibliometrics like pros. Stay up to date and Develop Literature Syntheses in the Biomedical Domain (14h) - Link: https://elearning.unito.it/strutture_universitarie/course/view.php?id=1321

16/03/2022 – MEDCap Policy Course & Medcap Policy Awareness Certificate (MPAC) UniTo - Link: https://elearning.unito.it/mooc/course/index.php?categoryid=7

03/2022 - Corso di formazione in materia di Igiene e Sicurezza - Rischio Alto in area sanitaria - Settore Ateco 2007 Q 86 - (D. Lgs. 81/08 s.m.i.) (12h)

 

SCIENTIFIC PUBLICATIONS

 

A.A. 2022/2023

• Alongi P, Rovera G, Stracuzzi F, Popescu CE, Minutoli F, Arnone G, Baldari S, Deandreis D, Caobelli F. Artificial Intelligence in Breast Cancer: A Systematic Review on PET Imaging Clinical Applications. Curr Med Imaging. 2023;19(8):832-843. doi: 10.2174/1573405619666230126093806. PMID: 36703586.

 

• Oderda M, Grimaldi S, Rovera G, Delsedime L, D'Agate D, Lavagno F, Marquis A, Marra G, Molinaro L, Deandreis D, Gontero P. Robot-assisted PSMA-radioguided Surgery to Assess Surgical Margins and Nodal Metastases in Prostate Cancer Patients: Report on Three Cases Using an Intraoperative PET-CT Specimen Imager. Urology. 2023 Sep 3:S0090-4295(23)00730-6. doi: 10.1016/j.urology.2023.08.013. Epub ahead of print. PMID: 37669707.

 

• Chierichetti F, Burroni L, Guglielmo P, Rovera G, Filice A. Raccomandazione per la definizione degli standard da adottare per la qualità delle immagini nel manuale di qualità, come previsto dal Dlgs 101/2020. Vrs. 01/2023.

 

• Rovera G, de Koster EJ, Rufini V, Zollino M, Zagaria L, Giammarile F, Vidal-Sicart S, Valdés Olmos R, Collarino A. ^99mTc-Tilmanocept performance for sentinel node mapping in breast cancer, melanoma, and head and neck cancer: a systematic review and meta-analysis from a European expert panel. Eur J Nucl Med Mol Imaging. 2023 Sep;50(11):3375-3389. doi: 10.1007/s00259-023-06290-5. Epub 2023 Jun 13. PMID: 37310426.

 

• Rovera G, Fariselli P, Deandreis D. Artificial Intelligence and Machine Learning in Nuclear Medicine. In: Endoradiotherapy. 1st ed. Springer; 2023 Nov.

 

• Rovera G, Grimaldi S, Oderda M, Finessi M, Giannini V, Passera R, Gontero P, Deandreis D. Machine Learning CT-Based Automatic Nodal Segmentation and PET Semi-Quantification of Intraoperative ⁶⁸Ga-PSMA-11 PET/CT Images in High-Risk Prostate Cancer: A Pilot Study. Diagnostics (Basel). 2023 Sep 21;13(18):3013. doi: 10.3390/diagnostics13183013. PMID: 37761380; PMCID: PMC10529304.

 

Completed under submission

• Guido Rovera, Luca Urso, Federica Stracuzzi, Riccardo Laudicella, Viviana Frantellizzi, Chiara Cottignoli, Maria Gazzilli, Priscilla Guglielmo, Stefano Panareo, Laura Evangelista, Angelina Filice, Luca Burroni, “Accreditamento e Management - HTA” AIMN Working Group. Advantages of the SiPM-based Digital PET/CT Technology in Nuclear Medicine Clinical Practice: a Systematic Review – Part 1 & Part 2

 

Submitted under evaluation

• Dall’Olio FG, Zrafi W, Roelants V, Ambrosini V, Rovera G, Novello S, Deandreis D, Garcia C, Besse B et al. Metabolic tumor burden assessed by ¹⁸F-FDG PET scan as a predictive biomarker for immune checkpoint blockers in advanced NSCLC and its biological correlates: a multicentric study.

 

• Rovera G, Grimaldi S, Dall’Armellina S, Zotta M, Finessi M, Passera R, Deandreis D. Comparison of digital versus analog ⁶⁸Ga-PSMA-11 PET/CT performance in hormone-sensitive prostate cancer patients with early biochemical recurrence or persistence after radical treatment.

 

A.A. 2021/2022

• Ceci F, Rovera G, Iorio GC, Guarneri A, Chiofalo V, Passera R, Oderda M, Dall'Armellina S, Liberini V, Grimaldi S, Bellò M, Gontero P, Ricardi U, Deandreis D. Event-free survival after 68Ga-PSMA-11 PET/CT in recurrent hormone-sensitive prostate cancer (HSPC) patients eligible for salvage therapy. Eur J Nucl Med Mol Imaging. 2022 Feb 26. doi: 10.1007/s00259-022-05741-9.

 

• Rovera G, Grimaldi S, Dall’Armellina S, Passera R, Oderda M, Iorio GC, Guarneri A, Gontero P, Ricardi U, Deandreis D. Predictors of Bone Metastases at 68Ga-PSMA-11 PET/CT in Hormone-Sensitive Prostate Cancer (HSPC) Patients with Early Biochemical Recurrence or Persistence. Diagnostics. 2022; 12(6):1309. https://doi.org/10.3390/diagnostics12061309

 

• Rovera G, Fariselli P, Deandreis D. Development of a REDCap-based workflow for high-volume relational data analysis on real-time data in a medical department using open source software. Comput Methods Programs Biomed. 2022 Sep 6;226:107111. doi: 10.1016/j.cmpb.2022.107111. PMID: 36108572.

 

• Rovera G, Polverari G, Ceci F. PSMA based PET imaging for initial diagnosis and staging of prostate cancer. In Evangelista L., Ceci F. Nuclear medicine in prostate cancer management. 1st ed. Torino: Minerva Medica Edizioni; 2022. ISBN: ISBN: 9788855321167

 

• Califaretti E & Dall'armellina S, Rovera G, Finessi M, Deandreis D. The role of PET/CT in thyroid autoimmune diseases. Q J Nucl Med Mol Imaging. 2022 May 25. doi: 10.23736/S1824-4785.22.03464-1. Epub ahead of print. PMID: 35612371.

 

PRESENTATION OF PAPERS, POSTERS, GIVEN SPEECHES AT CONFERENCES

 A.A. 2022/2023

• 11/09/2023 Poster (author): “Intraoperative PET/CT specimen imaging for the evaluation of surgical margins and nodal metastases in prostate cancer patients undergoing robot-assisted PSMA-radioguided surgery”

European Association of Nuclear Medicine (EANM) Congress, Vienna, 9-13 Sept 2023

 

• 10/09/2023 Poster (author): “Comparison of digital versus analog 68Ga-PSMA-11 PET/CT performance in hormone-sensitive prostate cancer patients with early biochemical recurrence or persistence”

European Association of Nuclear Medicine (EANM) Congress, Vienna, 9-13 Sept 2023

 

• 10/09/2023 Poster (author): “Multimodality approach with 68Ga-PSMA-11 PET/CT in staging high-risk prostate cancer patients candidate to radical prostatectomy”

European Association of Nuclear Medicine (EANM) Congress, Vienna, 9-13 Sept 2023

 

• 25/10/2022 Conference speech: "Neoplasie del cavo orale: la Medicina Nucleare"

“Corso teorico-pratico su patologie neuroradiologiche e sulle neoplasie del capocollo”, 24-25/10/2022, Turin, Italy

 

A.A. 2021/2022

• 18/10/2022 e-Poster presentation (author): "Prediction of M1b stage in prostate cancer patients undergoing ⁶⁸Ga-PSMA-11 PET/CT for early biochemical recurrence or persistence"

“EANM Congress 2022”, 15-19/10/2022, Barcellona, Spain

 

• 15/10/2022 Highlights and Oral presentation (co-author): "Computational Models for Patient Stratification in Molecular Radiotherapy (COMPASS): a first dataset analysis in hyperthyroid patients"

“EANM Congress 2022”, 15-19/10/2022, Barcellona, Spain

 

• 16/09/2022 Conference speech: "Nuclear Medicine molecular imaging for prostate cancer staging"

“Multidisciplinary Prostate Cancer Update Meeting”, 16/09/2022, Turin, Italy

 

• 24/06/2022 Conference speech: "Il nodulo tiroideo captante alla ¹⁸F-FDG PET/CT: cosa significa e cosa fare?"

“I venerdì della tiroide”, 24/06/2022, Online webinar, Italy

 

• 11/06/2022 e-Poster presentation (author): “Predictors of distant metastases at ⁶⁸Ga-PSMA-11 PET/CT in early-recurrent hormone-sensitive prostate cancer (HSPC) patients”

SNMMI Annual Meeting, 11-14/06/2022, Vancouver, Canada

 

• 13/05/2022 Oral presentation (author): “Predictors of bone metastases at ⁶⁸Ga-PSMA-11 PET/CT in hormone-sensitive prostate cancer (HSPC) patients with early biochemical recurrence or persistence”

XV Congresso Nazionale AIMN, 12-15/05/2022, Rimini, Italy

 

PARTICIPATION TO NATIONAL & INTERNATIONAL RESEARCH PROJECTS

• Horizon Europe Framework Programme (2023)

Project: Dynamic multiorgan and multiscale virtual twins for molecular radiotherapy

Role: Co-participant

 

• Multicenter Study – Italian Association of Nuclear Medicine (AIMN) (2023)

Project: 18F-FDG PET/CT in triple negative breast cancer: a multicenter real world experience from the Italian Association of Nuclear Medicine (AIMN)

Role: Co-participant

 

TEACHING ACTIVITIES AND STUDENTS’ MENTORSHIP

Institution: University of Turin, Turin, Italy

A.A. 2022/2023

Teaching activities

• Corso di Laurea in Infermieristica – Can. A/B/C (A.A. 2022/2023)

Course: Funzionamento del corpo umano - Diagnostica per immagini         Duration: 6 hours       Topics: ¹⁸F-FDG PET/CT

 

• Corso di Laurea in Infermieristica – Can. A/B/C (A.A. 2022/2023)

Course: Funzionamento del corpo umano - Diagnostica per immagini         Written / Oral Examination (Nuclear Medicine)       Duration: 5 sessions

 

• Corso di Laurea in Tecniche di Radiologia Medica, per Immagini e Radioterapia (A.A. 2022/2023)

Course: Medicina Nucleare II, Modulo Ricerca 4 - Medicina Nucleare         Duration: 12 hours       Topics: Nuclear Medicine clinical applications

 

• Corso di Laurea Magistrale in Medicina e Chirurgia – Can. A/B (A.A. 2022/2023)

Course: Diagnostica per immagini e Medicina Nucleare         Duration: 16 hours       Topics: Scintigraphic and PET/CT applications in nuclear medicine

 

• Corso di Laurea Magistrale in Medicina e Chirurgia – Can. A/B (A.A. 2022/2023)

Course: Diagnostica per immagini e Medicina Nucleare         Oral Examination (Nuclear Medicine)       Duration: 12 sessions

 

Undergraduate Students’ training and mentorship

• Medicine and Surgery - Graduation Thesis Project Mentorship

Project title: “Multimodality approach with 68Ga-PSMA-11 PET/TC, in high-risk prostate cancer patients candidate to radical prostatectomy”

 

• Nuclear Medicine – Specialization Thesis Project Mentorship

Project title: “Innovative use of 68 Ga-PSMA-11 in high risk prostate cancer patients: from staging to radioguided sugery”

 

Interdepartimental Projects Collaborations

• Project Title: “Predictive value of 18F-FDG PET/CT in treatment response assessment of patients with radioiodine-refractory thyroid cancer treated with Lenvatinib”

Department: Endocrinology, University of Turin

• Project Title: “Predictive value of baseline 18F-FDG PET/CT whole-body volumetric parameters in treatment response assessment of patients with radioiodine-refractory thyroid cancer treated with Lenvatinib”

Department: Endocrinology, University of Turin

• Project Title: “PSMA-guided management of recurrent post-prostatectomy patients”

Department: Radiotherapy, University of Turin

• Project Title: “PSMA-guided management of prostate cancer patients relapsing after prostatectomy and prostate-bed RT”

Department: Radiotherapy, University of Turin

 

A.A. 2021/2022

Teaching activities

• Corso di Laurea in Tecniche di Radiologia Medica, per Immagini e Radioterapia (A.A. 2021/2022)

Course: Medicina Nucleare         Duration: 2 hours       Topics: Renal scintigraphy

 

• Master Program in Molecular Biotechnology (A.A. 2021/2022)

Course: In vivo diagnostics: PET/SPECT/CT        Duration: 4 hours

Topics: 18F-FDG PET/CT in oncology, PET/CT applications in prostate cancer

 

• MedInTo Medicine and Surgery (Corso di Laurea Magistrale in Medicina e Chirurgia in lingua inglese) (A.A. 2021/2022)

Course: Medical Radiology     Duration: 2 hours     Topics: Basic concepts of Nuclear Medicine

 

• Corso di Laurea Magistrale in Medicina e Chirurgia (A.A. 2021/2022)

Course: Diagnostica per immagini e medicina nucleare            Duration: 2 hours

Topics: ¹⁸F-FDG PET/CT applications in oncology

 

• Corso di Laurea Magistrale in Medicina e Chirurgia (A.A. 2021/2022)

Course: ADE - Inquadramento diagnostico e indirizzi terapeutici delle principali patologie neoplastiche

Duration: 2 hours            Topics: PET/CT applications in prostate cancer and lung cancer

 

Undergraduate Students’ training and mentorship

• Medicine and Surgery - Undergraduate students’ internship training (A.A. 2021/2022)

Topic: PET/CT applications in Nuclear Medicine             Duration: 5 hours

 

• Medicine and Surgery - Graduation Thesis Project Mentorship

Project title: “Multimodality approach with ⁶⁸Ga-PSMA-11 PET/TC, in high-risk prostate cancer patients candidate to radical prostatectomy”

 

ACTIVE PARTICIPATION TO SCIENTIFIC ASSOCIATIONS ACTIVITIES

Active member of the Scientific Committee of the “Management and Health Technology Assessment (HTA)” study group of the Italian Association of Nuclear Medicine (AIMN)