Dottorato in Fisiopatologia Medica

1: Pignochino Y, Crisafulli G, Giordano G, Merlini A, Berrino E, Centomo ML, Chiabotto G, Brusco S, Basiricò M, Maldi E, Pisacane A, Leuci V, Sangiolo D, D'Ambrosio L, Aglietta M, Kasper B, Bardelli A, Grignani G. PARP1 Inhibitor and Trabectedin Combination Does Not Increase Tumor Mutational Burden in Advanced Sarcomas-A Preclinical and Translational Study. Cancers (Basel). 2021 Dec 15;13(24):6295. doi: 10.3390/cancers13246295. PMID: 34944915; PMCID: PMC8699802.

2: Debernardi C, Libera L, Berrino E, Sahnane N, Chiaravalli AM, Laudi C,
Berselli M, Sapino A, Sessa F, Venesio T, Furlan D. Evaluation of global and
intragenic hypomethylation in colorectal adenomas improves patient
stratification and colorectal cancer risk prediction. Clin Epigenetics. 2021 Aug
9;13(1):154. doi: 10.1186/s13148-021-01135-0. Erratum in: Clin Epigenetics. 2021
Sep 21;13(1):178. PMID: 34372923; PMCID: PMC8351348.

3: Berrino E, Bragoni A, Annaratone L, Fenocchio E, Carnevale-Schianca F,
Garetto L, Aglietta M, Sarotto I, Casorzo L, Venesio T, Sapino A, Marchiò C.
Pursuit of Gene Fusions in Daily Practice: Evidence from Real-World Data in
Wild-Type and Microsatellite Instable Patients. Cancers (Basel). 2021 Jul
5;13(13):3376. doi: 10.3390/cancers13133376. PMID: 34282766; PMCID: PMC8269381.

4: Annaratone L, De Palma G, Bonizzi G, Sapino A, Botti G, Berrino E, Mannelli
C, Arcella P, Di Martino S, Steffan A, Daidone MG, Canzonieri V, Parodi B,
Paradiso AV, Barberis M, Marchiò C; Alleanza Contro il Cancro (ACC) Pathology
and Biobanking Working Group. Basic principles of biobanking: from biological
samples to precision medicine for patients. Virchows Arch. 2021
Aug;479(2):233-246. doi: 10.1007/s00428-021-03151-0. Epub 2021 Jul 13. PMID:
34255145; PMCID: PMC8275637.

5: Enriquez C, Cancila V, Ferri R, Sulsenti R, Fischetti I, Milani M, Ostano P,
Gregnanin I, Mello-Grand M, Berrino E, Bregni M, Renne G, Tripodo C, Colombo MP,
Jachetti E. Castration-Induced Downregulation of SPARC in Stromal Cells Drives
Neuroendocrine Differentiation of Prostate Cancer. Cancer Res. 2021 Aug
15;81(16):4257-4274. doi: 10.1158/0008-5472.CAN-21-0163. Epub 2021 Jun 21. PMID:
34185677.

6: Simonetti M, Zhang N, Harbers L, Milia MG, Brossa S, Huong Nguyen TT, Cerutti
F, Berrino E, Sapino A, Bienko M, Sottile A, Ghisetti V, Crosetto N. COVseq is a
cost-effective workflow for mass-scale SARS-CoV-2 genomic surveillance. Nat
Commun. 2021 Jun 23;12(1):3903. doi: 10.1038/s41467-021-24078-9. PMID: 34162869;
PMCID: PMC8222401.

7: Berrino E, Balsamo A, Pisacane A, Gallo S, Becco P, Miglio U, Caravelli D,
Poletto S, Paruzzo L, Debernardi C, Piccinelli C, Zaccagna A, Rescigno P,
Aglietta M, Sapino A, Carnevale-Schianca F, Venesio T. High BRAF variant allele
frequencies are associated with distinct pathological features and
responsiveness to target therapy in melanoma patients. ESMO Open. 2021
Jun;6(3):100133. doi: 10.1016/j.esmoop.2021.100133. Epub 2021 May 10. PMID:
33984673; PMCID: PMC8134716.

8: Petrelli A, Bellomo SE, Sarotto I, Kubatzki F, Sgandurra P, Maggiorotto F, Di
Virgilio MR, Ponzone R, Geuna E, Galizia D, Nuzzo AM, Medico E, Miglio U,
Berrino E, Venesio T, Ribisi S, Provero P, Sapino A, Giordano S, Montemurro F.
MiR-100 is a predictor of endocrine responsiveness and prognosis in patients
with operable luminal breast cancer. ESMO Open. 2020 Oct;5(5):e000937. doi:
10.1136/esmoopen-2020-000937. PMID: 33122354; PMCID: PMC7597498.

9: Chiabotto G, Grignani G, Todorovic M, Martin V, Centomo ML, Prola E, Giordano
G, Merlini A, Miglio U, Berrino E, Napione L, Isella C, Capozzi F, Basiricò M,
Marsero C, Gerardi I, Venesio T, Sangiolo D, Aglietta M, D'Ambrosio L,
Pignochino Y. Pazopanib and Trametinib as a Synergistic Strategy against
Osteosarcoma: Preclinical Activity and Molecular Insights. Cancers (Basel). 2020
Jun 10;12(6):1519. doi: 10.3390/cancers12061519. PMID: 32531992; PMCID:
PMC7352822.

10: Racanelli D, Brenca M, Baldazzi D, Goeman F, Casini B, De Angelis B, Guercio
M, Milano GM, Tamborini E, Busico A, Dagrada G, Garofalo C, Caruso C, Brunello
A, Pignochino Y, Berrino E, Grignani G, Scotlandi K, Parra A, Hattinger CM,
Ibrahim T, Mercatali L, De Vita A, Carriero MV, Pallocca M, Loria R, Covello R,
Sbaraglia M, Dei Tos AP, Falcioni R, Maestro R. Next-Generation Sequencing
Approaches for the Identification of Pathognomonic Fusion Transcripts in
Sarcomas: The Experience of the Italian ACC Sarcoma Working Group. Front Oncol.
2020 Apr 15;10:489. doi: 10.3389/fonc.2020.00489. Erratum in: Front Oncol. 2020
Jun 23;10:944. PMID: 32351889; PMCID: PMC7175964.

11: Annaratone L, Cascardi E, Vissio E, Sarotto I, Chmielik E, Sapino A, Berrino
E, Marchiò C. The Multifaceted Nature of Tumor Microenvironment in Breast
Carcinomas. Pathobiology. 2020;87(2):125-142. doi: 10.1159/000507055. Epub 2020
Apr 23. PMID: 32325459; PMCID: PMC7265767.

12: Berrino E, Annaratone L, Miglio U, Maldi E, Piccinelli C, Peano E,
Balmativola D, Cassoni P, Pisacane A, Sarotto I, Venesio T, Sapino A, Marchiò C.
Cold Formalin Fixation Guarantees DNA Integrity in Formalin Fixed Paraffin
Embedded Tissues: Premises for a Better Quality of Diagnostic and Experimental
Pathology With a Specific Impact on Breast Cancer. Front Oncol. 2020 Feb
19;10:173. doi: 10.3389/fonc.2020.00173. PMID: 32140450; PMCID: PMC7042205.

13: Marchiò C, Annaratone L, Marques A, Casorzo L, Berrino E, Sapino A. Evolving
concepts in HER2 evaluation in breast cancer: Heterogeneity, HER2-low carcinomas
and beyond. Semin Cancer Biol. 2021 Jul;72:123-135. doi:
10.1016/j.semcancer.2020.02.016. Epub 2020 Feb 26. PMID: 32112814.

14: D'Ambrosio C, Erriquez J, Arigoni M, Capellero S, Mittica G, Ghisoni E,
Borella F, Katsaros D, Privitera S, Ribotta M, Maldi E, Di Nardo G, Berrino E,
Venesio T, Ponzone R, Vaira M, Hall D, Jimenez-Linan M, Paterson AL, Calogero
RA, Brenton JD, Valabrega G, Di Renzo MF, Olivero M.
PIK3R1^W624R Is an Actionable Mutation in High Grade Serous
Ovarian Carcinoma. Cells. 2020 Feb 14;9(2):442. doi: 10.3390/cells9020442. PMID:
32075097; PMCID: PMC7072782.

15: Varamo C, Peraldo-Neia C, Ostano P, Basiricò M, Raggi C, Bernabei P, Venesio
T, Berrino E, Aglietta M, Leone F, Cavalloni G. Establishment and
Characterization of a New Intrahepatic Cholangiocarcinoma Cell Line Resistant to
Gemcitabine. Cancers (Basel). 2019 Apr 11;11(4):519. doi:
10.3390/cancers11040519. PMID: 30979003; PMCID: PMC6520787.

16: Miglio U, Berrino E, Panero M, Ferrero G, Coscujuela Tarrero L, Miano V,
Dell'Aglio C, Sarotto I, Annaratone L, Marchiò C, Comoglio PM, De Bortoli M,
Pasini B, Venesio T, Sapino A. The expression of LINE1-MET chimeric transcript
identifies a subgroup of aggressive breast cancers. Int J Cancer. 2018 Dec
1;143(11):2838-2848. doi: 10.1002/ijc.31831. Epub 2018 Oct 4. PMID: 30144023.

17: Marchiò C, Dell'Orto P, Annaratone L, Geyer FC, Venesio T, Berrino E, Verdun
di Cantogno L, Garofoli A, Rangel N, Casorzo L, dell'Aglio C, Gugliotta P,
Trisolini E, Beano A, Pietribiasi F, Orlassino R, Cassoni P, Pich A, Montemurro
F, Mottolese M, Vincent-Salomon A, Penault-Llorca F, Medico E, Ng CKY, Viale G,
Sapino A. The Dilemma of HER2 Double-equivocal Breast Carcinomas: Genomic
Profiling and Implications for Treatment. Am J Surg Pathol. 2018
Sep;42(9):1190-1200. doi: 10.1097/PAS.0000000000001100. PMID: 29975246; PMCID:
PMC6110371.

18: Bussolati G, Annaratone L, Berrino E, Miglio U, Panero M, Cupo M, Gugliotta
P, Venesio T, Sapino A, Marchiò C. Acid-free glyoxal as a substitute of formalin
for structural and molecular preservation in tissue samples. PLoS One. 2017 Aug
10;12(8):e0182965. doi: 10.1371/journal.pone.0182965. PMID: 28796828; PMCID:
PMC5552132.

19: Errichiello E, Vetro A, Mina T, Wischmeijer A, Berrino E, Carella M,
Romagnoli M, Sacchini P, Venesio T, Zecca M, Zuffardi O. Whole exome sequencing
in the differential diagnosis of Diamond-Blackfan anemia: Clinical and molecular
study of three patients with novel RPL5 and mosaic RPS19 mutations. Blood Cells
Mol Dis. 2017 May;64:38-44. doi: 10.1016/j.bcmd.2017.03.002. Epub 2017 Mar 6.
PMID: 28376382; PMCID: PMC7129236.

20: Furlan D, Trapani D, Berrino E, Debernardi C, Panero M, Libera L, Sahnane N,
Riva C, Tibiletti MG, Sessa F, Sapino A, Venesio T. Oxidative DNA damage induces
hypomethylation in a compromised base excision repair colorectal tumourigenesis.
Br J Cancer. 2017 Mar 14;116(6):793-801. doi: 10.1038/bjc.2017.9. Epub 2017 Jan
31. PMID: 28141798; PMCID: PMC5355935.

21: Marabelli M, Molinaro V, Abou Khouzam R, Berrino E, Panero M, Balsamo A,
Venesio T, Ranzani GN. Colorectal Adenomatous Polyposis: Heterogeneity of
Susceptibility Gene Mutations and Phenotypes in a Cohort of Italian Patients.
Genet Test Mol Biomarkers. 2016 Dec;20(12):777-785. doi: 10.1089/gtmb.2016.0198.
Epub 2016 Oct 5. PMID: 27705013.

Book Chapter:

Enrico Berrino, Caterina Marchiò "I riarrangiamenti dei geni NTRK e il loro significato biologico" in Riarrangiamenti del gene NTRK nei tumori solidi Il primo modello di test e di terapia target “agnostica” A cura di Nicola Normanno e Carmine Pinto

*in italic manuscripts published during Ph.D period

** underlined the first authorship 

1st Year

1st Year

1st Year

- Webinar cBioPortal Instructional Webinars". Date Time: Apr 30, 2020 11:00 AM Eastern Time (US and Canada) Every week on Thu, 5 occurrence(s) Apr 30, 2020 11:00 AM May 7, 2020 11:00 AM May 14, 2020 11:00 AM May 21, 2020 11:00 AM May 28, 2020 11:00 AM

- Webinar "Insights into KRAS biology to identify potential therapeutic strategies" by Dr. Chiara Ambrogio -Molecular Biotechnology Center-University of Torino Department of Medical Oncology, Dana-Farber Cancer Institute - Boston 2.00 PM - Friday 17 April 2020 

- February 17th, 1.30pm Aula Cappa Nicola Crosetto, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden  New methods to study genome architecture and structural variation in cancerWednesday 12 th February 2020 At 10.00 – Aula Cappa - 1st floor “Introducing Human Technopole” Prof. Iain Mattaj, Director Human Technopole Milano

- Wednesday 15 Jan 2020 Non-coding RNAs and cancer: an overview on cancer development
and therapy George A. Calin Department of Experimental Therapeutics, MD Anderson Cancer Center

- November 18 2019 in Cappa Lecture Hall,  Dr. Francesco Iorio (Cancer DepMap Analytics Team Wellcome Sanger Institute– CAMBRIDGE – UK) will hold the seminar entitled “Prioritising cancer therapeutic targets via CRISPR-Cas9 screens and multi-omics data integration”.  

- November 18 2019 in Cappa Lecture Hall  Dr. Brian Underdown (Former Associate Dean of Research, University of Toronto’s Faculty of Medicine and McMaster University’s Faculty of Health Sciences) will give a seminar entitled  ‘Challenges of cancer vaccines, adoptive immunotherapy and T cell therapy’ 

Update on physiology of hypertension. Prof. Franco Veglio - 6 Giugno 2019

How to write a scientific paper. Prof. Riccarda granata - 27 Giugno 2019

Regression models for prognostic research. Prof. Milena Maule - 18 Luglio 2019

Scientific presentations. Prof. Benedetta Bussolati - 19 Settembre 2019

Alteration of intestinal microbioma as organ insufficiency: a microbiological point of view. Prof. Rossana Cavallo 28/7/21

Precision medicine in oncology: Putting drivers and targets in context. Prof. Livio Trusolino 2/09/21

Clinical trials in oncology: Failures and successes.. Prof. Livio Trusolino 27/09/21