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Logo di Dottorato in Fisiopatologia Medica

Scuola di Dottorato

Dottorato in Fisiopatologia Medica

Logo di Dottorato in Fisiopatologia Medica

Dott. Paolo Bottino

Tesi di dottorato

Impact of gut Microbioma on clinical management of critical patients.

Background. By the end of February 2022, the COVID-19 pandemic had maintained its severity despite diverse strategies and increased vaccination rates worldwide; Although clinical studies have revealed that adults and immunocompromised patients present with more severe disease, SARS-CoV-2 infection has also significantly impacted the pediatric population. Whilst hospitalization, ICU stays and mortality rates have also been lowered in this patient cohort, COVID-19 can cause a long-term complication, so-called Multiple Systemic Inflammatory Syndrome in Children (MIS-C); MIS-C is a severe inflammatory disease characterized by fever, rash, conjunctivitis, gastrointestinal symptoms and myocardial dysfunction in children/infants who have SARS-COV-2 positivity or a history of exposure approximately 4–6 weeks before the onset of symptoms. An autoimmune-mediated inflammatory process after infection, a cytokine storm initiated by a superantigen response, and a dysregulated immune response to exposure to SARS-CoV-2 viral antigens have been proposed as theories to explain its pathogenesis. Moreover, it has been shown that infections in the gastrointestinal and respiratory districts, have effects on microbiota composition.

Although the functional properties of the complex gut microbiome still remain not fully understood, it is thought that microbial composition may play a role in the development, prognosis and evolution of MIS-C after COVID-19 infection. Thus, the aim of this study was to evaluate gut microbiome composition in order to clarify a possible correlation between SARS-CoV-2 infection and development of MIS-C.

Objectives. Aim of this work is the analysis of Gut Microbiome in MIS-C and COVID-19 patients and the evaluation of potential differences in terms of α and β diversity, microbial richness in order to define a correlation between development of MIS-C and viral infection. The analysis will be useful to define an in-depth evaluation of this ciritical inflammatory condition.

Study design. For each enrolled children enrolled with MIS-C or COVD-19 infection, a stool samples was collected in order to evaluate the change in gut microbiome relating to disease conditionds. Cumulative results of the two subsets will be compared between them and related to patients’ clinical condition and outcome. The expected number of patients involved in the present study will be 80 in the first 20 months.

Expected results and relevance for the national health service. Results obtained from correlation of dysbiosis of MIS-C/COVID-19 patients and pathophysiological outcome should be useful to understand risk factors and predictors related to the disease development.

The overall results of this analysis could be useful to better understand the interactions between gut microbiome and clinical outcome of this inflammatory severe disease, thus allowing a better management of patients with MIS-C.

Attività di ricerca

Activity of clinical microbiology and diagnostic in the following fields:

  • Bacteriology;
  • Molecular biology;
  • Virology;
  • Parassitology;
  • Mycology.

Collaboration and scientific consultancy with biomedical companies for testing and developing of diagnostic tests.

Support to molecular biology activities during COVID-19 pandemic.

Activiy of research in the following fields:

  • Molecular biology;
  • Sequencing;
  • NGS and microbiome;
  • Whole Genome Sequencing;
  • Viral infections;
  • High-Throughput diagnostic automated platforms.

Pubblication of research product (articles, posters, abstracts) on national and international journals and partecipation to microbiology congress and theoretical/pratical training courses.

 

Pubblicazioni

 

Articoli:

  • Bottino P, Massarino C, Leli C, Scomparin E, Bara C, Gotta F, Cornaglia E, Felici E, Gentile M, Ranzan S, et al. Evaluation of a Commercial Rapid Molecular Point-of-Care Assay for Differential Diagnosis Between SARS-CoV-2 and Flu A/B Infections in a Pediatric Setting. Viruses. 2024; 16(10):1638. DOI: 10.3390/v16101638.
  • Bottino P, Vay D, Leli C, Ferrara L, Pizzo V, Gotta F, Raiteri A, Rapallo F, Roveta A, Maconi A, Rocchetti A. Evaluation of Bacterial Viability for Fecal Microbiota Transplantation: Impact of Thawing Temperature and Storage Time. Microorganisms. 2024 Jun 25;12(7):1294. DOI: 10.3390/microorganisms12071294.
  • Curtoni A, Pastrone L, Cordovana M, Bondi A, Piccinini G, Genco M, Bottino P, Polizzi C, Cavallo L, Mandras N, Corcione S, Montrucchio G, Brazzi L, Costa C. Fourier Transform Infrared Spectroscopy Application for Candida auris Outbreak Typing in a Referral Intensive Care Unit: Phylogenetic Analysis and Clustering Cut-Off Definition. Microorganisms. 2024 Jun 27;12(7):1312. DOI: 10.3390/microorganisms12071312.
  • Bottino P, Pastrone L, Zanotto E, Sidoti F, Cavallo R, Costa C. Molecular diagnosis of Cytomegalovirus infection: clinical performance of the Aptima transcription-mediated amplification assay toward conventional qPCR chemistry on whole blood samples. J Clin Microbiol. 2024 Mar 13;62(3):e0090623. DOI: 10.1128/jcm.00906-23.
  • Leli C, Ferrara L, Bottino P, Bara C, Megna I, Penpa S, Felici E, Maconi A, Rocchetti A. Application of a SARS-CoV-2 Antigen Rapid Immunoassay Based on Active Microfluidic Technology in a Setting of Children and Young Adults. Viruses. 2023 Dec 26;16(1):41. DOI: 10.3390/v16010041.
  • Bottino P, Pizzo V, Castaldo S, Scomparin E, Bara C, Cerrato M, Sisinni S, Penpa S, Roveta A, Gerbino M, Maconi A, Rocchetti A. Clinical Evaluation and Comparison of Two Microfluidic Antigenic Assays for Detection of SARS-CoV-2 Virus. Microorganisms. 2023 Nov 5;11(11):2709. DOI: 10.3390/microorganisms11112709.
  • Genco M, Curtoni A, Bottino P, Scabini S, Corcione S, Vita D, Guarrasi L, Bianco G, Bondi A, Risso D, Cavallo R, Costa C. First case of Chryseobacterium gallinarum bloodstream infection: a diagnostic and therapeutic challenge for an emerging pathogen. New Microbiol. 2024 Jan;46(4):412-415. DOI: N/A.
  • Bottino P, Pastrone L, Curtoni A, Bondi A, Sidoti F, Zanotto E, Cavallo R, Solidoro P, Costa C. Antiviral Approach to Cytomegalovirus Infection: An Overview of Conventional and Novel Strategies. Microorganisms. 2023 Sep 22;11(10):2372. DOI: 10.3390/microorganisms11102372.
  • Bottino P, Zanotto E, Sidoti F, Pastrone L, Piva R, Mereu E, Costa C, Cavallo R. Extraction Bottleneck in the Diagnosis of SARS-CoV-2: Evaluation of an Alternative Protocol Derived from Veterinary Use. Microorganisms. 2023; 11(2) 2):535. DOI: 10.3390/microorganisms11020535
  • Pastrone L, Curtoni A, Criscione G, Scaiola F, Bottino P, Guarrasi L, Iannaccone M, Timke M, Costa C, Cavallo R. Evaluation of Two Different Preparation Protocols for MALDI TOF MS Nontuberculous Mycobacteria Identification from Liquid and Solid Media. Microorganisms. 2023 Jan 3;11(1):120. DOI: 10.3390/microorganisms11010120
  • Bottino P, Zanotto E, Sidoti F, Pastrone L, Piva R, Mereu E, Costa C, Cavallo R. Extraction Bottleneck in the Diagnosis of SARS-CoV-2: Evaluation of an Alternative Protocol Derived from Veterinary Use. Microorganisms. 2023 Feb 20;11(2):535. DOI: 3390/microorganisms11020535
  • Pastrone L, Curtoni A, Criscione G, Scaiola F, Bottino P, Guarrasi L, Iannaccone M, Timke M, Costa C, Cavallo R. Evaluation of Two Different Preparation Protocols for MALDI-TOF MS Nontuberculous Mycobacteria Identification from Liquid and Solid Media. Microorganisms. 2023 Jan 3;11(1):120. DOI: 10.3390/microorganisms11010120
  • Peradotto M, Bondi A, Lombardi D, Bottino P, Zanotto E, Barbui AM, Cavallo R. The impact of COVID-19 pandemic control on vaccine-preventable invasive bacterial diseases in Piedmont (Italy). 2022 Feb 16:1–4. DOI: 10.1007/s15010-022-01770-6
  • Marchino M, Rizzo F, Barzanti P, Sparasci OA, Bottino P, Vicari N, Rigamonti S, Braghin S, Aaziz R, Vorimore F, Ru G, Laroucau K, Mandola ML. Chlamydia Species and Related Risk Factors in Poultry in North-Western Italy: Possible Bird-to-Human Transmission for C. gallinacea. Int J Environ Res Public Health. 2022 Feb 15;19(4):2174. DOI: 10.3390/ijerph19042174
  • Bottino P, Miglino R, Pastrone L, Barbui AM, Botta G, Zanotto E, Sidoti F, Costa C, Cavallo R. Clinical features of respiratory syncytial virus bronchiolitis in an infant: rapid and fatal brain involvement. BMC Pediatrics. 2021 Dec 9;21(1):556. DOI: 10.1186/s12887-021-03045-9
  • Spadea L, Zanotto L, Cavallo R, Campagna G, Giannico MI, Costagliola C, ELOOM Study Investigators. Effectiveness of Liposomal Ozonised Oil in Reducing Ocular Microbial Flora in Patients Undergoing Cataract Surgery. J Cataract Refract Surg. 2021. DOI: 10.1097/j.jcrs.0000000000000672
  • Peradotto M, Rolle E, Zaccaria T, Cavallero S, Bondi A, Bottino P, De Angelis C, D'Amelio S, Saracco GM, Cavallo R. An unpleasant souvenir: Endoscopic finding of Trichuris trichiura (Nematoda: Trichuridae). Parasitol Int. 2021 Feb;80:102220. DOI: 10.1016/j.parint.2020.102220
  • Mencucci R, Favuzza E, Bottino P, Mazzantini C, Zanotto E, Pellegrini-Giampietro D, Landucci E. A new ophthalmic formulation containing antiseptics and dexpanthenol: In vitro antimicrobial activity and effects on corneal and conjunctival epithelial cells. Experimental Eye Research. 2020;108269. DOI: 10.1016/j.exer.2020.108269
  • Zanotto E, Allesina A, Barreca A, Sidoti F, Gallo E, Bottino P, Iannaccone M, Bianco G, Biancone L, Cavallo R, Costa C. Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015-19. Viruses. 2020;12(9):E1047. DOI: 10.3390/v12091047
  • Petrillo S, Carrà G, Bottino P, Zanotto E, De Santis MC, Margaria JP, Giorgio A, Mandili G, Martini M, Cavallo R, Barberio D, Altruda F. A Novel Multiplex qRT-PCR Assay to Detect SARS-CoV-2 Infection: High Sensitivity and Increased Testing Capacity. Microorganisms. 2020;8(7):1064. DOI: 10.3390/microorganisms8071064
  • Carosso A, Revelli A, Gennarelli G, Canosa S, Cosma S, Borella F, Tancredi A, Paschero C, Boatti L, Zanotto E, Sidoti F, Bottino P, Costa C, Cavallo R, Benedetto C. Controlled ovarian stimulation and progesterone supplementation affect vaginal and endometrial microbiota in IVF cycles: a pilot study. J Assist Reprod Genet. 2020. DOI: 10.1007/s10815-020-01878-4
  • Bottino P, Balloco C, Rittà M, Bianco G, Sidoti F, Cavallo R, Costa C. Evaluation of CMV DNA in dried blood spot. The new Microbiologica. 2020;43(2). PMID: 32310302
  • Bottino P, Rapallo F, Gamalero E, Rocchetti A. Performance of a new combination of blood culture vials in sepsis detection: a 2-year retrospective comparison. European Journal of Clinical Microbiology & Infectious Diseases. 2019;38(8):1435 -1441. DOI: 10.1007/s10096-019-03568-1
  • Rocchetti A, Di Matteo L, Bottino P, Foret B, Gamalero E, Calabresi A et al. Prospective study of the clinical performance of three BACTEC media in a modern emergency department: Plus Aerobic/F, Plus Anaerobic/F, and Anaerobic Lytic/F. Journal of Microbiological Methods. 2016;130:129 -132. DOI: 10.1016/j.mimet.2016.09.008

§ Rocchetti A, Rapallo F, Bottino P, Mastrazzo A. Implementation of satellite blood-culture system in an emergency department: impact of time-to results in sepsis detection. Microbiologia Medica. 2016;31(2). DOI: 10.4081/mm.2016.5859

 

Poster:

  • Bottino P, Scaglione S, Incarbone L, Di Matteo L, Leli C, Rocchetti A. Evaluation of a rapid antibiotic susceptibility testing system on multidrug-resistant Gram-negative bacteria responsible for non-bloodstream infections: preliminary data. Poster presentato a 34th Congresso Internazionale ECCMID 2024.
  • Vay D, Bottino P, Raiteri A, Rapallo F, Rocchetti A. Recurrent clostridioides difficile infection and fecal microbiota transplant: impact of thawing temperature and storage time on bacterial viability. Poster Poster presentato a 51° Congresso Nazionale AMCLI 2024, Rimini.
  • Leli C, Bottino P, Scaglione S, Vay D, Ferrara L, Di Matteo L, Pizzo V, Castaldo S, Scomparin E, Ciriello MM, Boverio R, Rocchetti A. Characteristics of patients with positive blood cultures for carbapenemase-producing organisms at the emergency department. A case series from Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo of Alessandria. Poster presentato a 51° Congresso Nazionale AMCLI 2024, Rimini.
  • Leli C, Cornaglia E, Bottino P, Scaglione S, Vay D, Ferrara L, Di Matteo L, Gotta F, Cerrato M, Cavallo V, Berta E, Leone M, Rocchetti A. Comparison of serum igm and igg titres against Legionella pneumophila between patients with positive and negative urinary antigen. Our experience at the Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo of Alessandria. Poster Poster presentato a 51° Congresso Nazionale AMCLI 2024, Rimini.
  • Bottino P, Gotta F, Vay D, Pizzo V, Ferrara L, Gota C, Novi ML, Rocchetti A. Evolution of intestinal microbiota and role of fecal microbiota transplant for Clostridioides difficile recurrent infection management: a one-year experience in a tertiary regional hospital. Poster Poster presentato a 51° Congresso Nazionale AMCLI 2024, Rimini.
  • Bottino P, Gotta F, Vay D, Di Matteo L, Leli C, Pizzo V, Scaglione S, Rocchetti A. Evaluation of targeted next generation sequencing for the identification of the mycobacterium tuberculosis complex and nontuberculous mycobacteria: preliminary data. Poster Poster presentato a 51° Congresso Nazionale AMCLI 2024, Rimini.
  • Bottino P, Balloco C, Varetto S, Callipo A, Mantelli S, Piasentin EA, Frisicale L, Cuccu R, Alizzi S, Ranieri F, Arauco Rivera SR, Pastrone L, Zanotto E, Sidoti F, Costa C, Cavallo R. Molecular diagnosis of Cytomegalovirus infection: clinical performance of Transcription Mediated Amplification (TMA) kit towards conventional qPCR chemistry on whole blood samples. Poster presentato a 33rd Congresso Internazionale ECCMID 2023.
  • Bondi A,Barbui AM, Casale R, Bottino P, Costa C, Cavallo R. Valutazione del panello multiplex biofire® joint infection per la diagnosi microbiologica di infezione articolare. Poster presentato a 50° Congresso Nazionale AMCLI 2023, Rimini.
  • Bottino P, Balloco C, Varetto S, Callipo A, Mantelli S, Piasentin EA, Frisicale L, Cuccu R, Alizzi S, Ranieri F, Arauco Rivera SR, Zanotto E, Sidoti F, Costa C, Cavallo R. Pooling procedure for sars-cov-2 detection: comparison between qpcr and tma (transcription mediated amplification) chemistries. Poster presentato a 50° Congresso Nazionale AMCLI 2023, Rimini.
  • Bottino P, Pastrone L, Alizzi S, Avolio M, Pittaluga F, Sacchi A, Zanotto E, Sidoti F, Costa C, Cavallo R. A case of legionella longbeachae pneumonia and clinical usefulness of serological differential diagnosis. Poster presentato a 50° Congresso Nazionale AMCLI 2023, Rimini.
  • Zanotto E, Sidoti F, Bottino P, Costa C, Cavallo R. Evaluation of cellular response and production of Interferon-γ to CMV in transplant patients. Poster presentato a 6th Congresso Nazionale SIV-ISV 2022.
  • Zanotto E, Bottino P, Sidoti F, Costa C, Cavallo R. Epidemiology of Influenza A, B and RSV during the period of the SARS CoV 2 Pandemic. Poster presentato a 6th Congresso Nazionale SIV-ISV 2022.
  • Bottino P, Zanotto E, Sidoti F, Pastrone L, Balloco C, Mantelli S, Varetto S, Frisicale L, Callipo A, Piasentin E A, Alizzi S, Cuccu R, Arauco Rivera S R, Ranieri F, Costa C, Cavallo R. Different diagnostic applications of a novel multiplex RT-qPCR assay for detection of SARS-CoV-2 infection. Poster presentato a 32nd Congresso Internazionale ECCMID 2022
  • Pastrone L, Curtoni A, Criscione G, Scaiola F, M. Sorba, Bottino P, Iannaccone M, Cavallo R. Comparison of two different preparation protocols for MALDI-TOF MS Nontuberculous Mycobacteria identification: preliminary results. Poster presentato a 32nd Congresso Internazionale ECCMID 2022.
  • Zanotto E, Bottino P, Sidoti F, Costa C, Cavallo R. Evaluation of the nasal microbiome in SARS-CoV-2 positive patients. Poster presentato a XLIX Congresso Nazionale AMCLI 2022, Rimini.
  • Pastrone L, Curtoni A, Iannaccone M, Bottino P, Sorba M, Quaranta R, Benvenga V, Lombardo M, Dobric B, Costa C, Cavallo R. Impact of the first COVID-19 pandemic wave on the microbiological diagnosis of mycobacteria infections in a north-west italian tertiary teaching hospital. Poster presentato a XLIX Congresso Nazionale AMCLI 2022, Rimini.
  • Bottino P, Zanotto E, Balloco C, Varetto S, Mantelli S, Frisicale L, Callipo A, Arauco Rivera S R, Cuccu R, Alizzi S, Pastrone L, Sidoti F, Costa C, Cavallo R. Implementation and evaluation of a qpcr kit for SARS-CoV-2 detection on the automated platform Panther Fusion system. Poster presentato a XLIX Congresso Nazionale AMCLI 2022, Rimini.
  • Pastrone L, Curtoni A, Criscione G, Scaiola F, Sorba M, Bottino P, Iannaccone M, Costa C, Cavallo R. MALDI-TOF MS for nontuberculous mycobacteria identification: evaluation of two different preparation protocols. Poster presentato a XLIX Congresso Nazionale AMCLI 2022, Rimini.
  • Bottino P, Zanotto E, Balloco C, Varetto S, Mantelli S, Frisicale L, Callipo A, Piasentin E A, Cuccu R, Arauco Rivera S R, Alizzi S, Pastrone L, Sidoti F, Costa C, Cavallo R. Reconfiguration of a clinical microbiology laboratory in response to COVID-19 emergency: one-year retrospective analysis in a North-West Italian tertiary teaching hospital. Poster presentato a XLIX Congresso Nazionale AMCLI 2022, Rimini.
  • Sidoti F, Bottino P, Zanotto E, Balloco C, Varetto S, Mantelli S, Frisicale L, Callipo A, Cuccu R, Arauco Rivera S R, Alizzi S, Costa C, Cavallo R. SARS-CoV-2 saliva screening testing in schools: a Turin surveillance experience. Poster presentato a XLIX Congresso Nazionale AMCLI 2022, Rimini.
  • Salerno C, Palin L, Milan I, Bottino P. Epidemiologia dell’infezione da SARS-COV-2 nel Piemonte orientale: valutazione retrospettiva nella provincia di Vercelli. Poster presentato a XI Congresso Nazionale SISMEC 2021.
  • Bondi A, Bottino P, Peradotto M, Zanotto E, Barbui AM, Costa C, Cavallo R. Haemophilus influenzae serotype distribution in Piedmont (Italy): results of 8 years of surveillance. Poster presentato a 31st Congresso Internazionale ECCMID 2021.
  • Zanotto E, Bottino P, Peradotto M, Barbui AM, Sidoti F, Costa C, Cavallo R. Development of a protocol for in vitro polymicrobial biofilm production. Poster presentato a 31st Congresso Internazionale ECCMID 2021.
  • Zanotto E, Bottino P, Bondi A, Sidoti F, Costa C, Cavallo R. Characterisation of the ocular microbial flora in patients undergoing cataract surgery. Poster presentato a 31st Congresso Internazionale ECCMID 2021.
  • Bottino P, Zanotto E, Genco M, Piva R, Mereu E, Sidoti F, Costa C, Cavallo R. Extraction bottleneck in the diagnosis of Sars-CoV-2: evaluation of an alternative protocol derived from veterinary use. Poster presentato a 31st Congresso Internazionale ECCMID 2021.
  • Bottino P, Zanotto E, Balloco C, Varetto S, Alizzi S, Sidoti F, Costa C, Cavallo R. SARS-CoV-2 diagnosis: implementation of a qPCR Kit on the automated platform Panther Fusion® system. Poster presentato a 5th Congresso Nazionale SIV-ISV 2021.
  • Riccobono E, Spanu T, Allegrucci F, Tiberio C, Ambretti S, Bottino P, Ghisetti V, Lo Cascio G, Rossolini GM. Multi-centre study for the evaluation of BioFire FilmArray Pneumonia Plus for the rapid microbiological diagnosis of low respiratory tract infections. Poster presentato a 30th Congresso Internazionale ECCMID 2020, Parigi.
  • Peradotto M, Zaccaria T, Cavallero S, Bondi A, Bottino P, Costa C, D’Amelio S, Cavallo R. “Seek and ye shall find”: endoscopic finding and molecular diagnosis of Trichuris trichiura. Poster presentato a 30th Congresso Internazionale ECCMID 2020, Parigi.
  • Bottino P, Zanotto E, Balloco C, Callipo A, Frisicale L, Mantelli S, Piasentin AE, Varetto S, Sidoti F, Avolio M, Costa C, Cavallo R. valutazione dei test rapidi standard f influenza a/b fia e rsv ag fia (sd biosensor) nella rilevazione di patogeni respiratori. Poster presentato a XLVIII Congresso Nazionale AMCLI 2019, Rimini.
  • Bondi A, Bottino P, Peradotto M, Zanotto E, Barbui AM, Sidoti F, Cavallo R. Isolamento di saprochaete spp da liquor in paziente ematologico con idrocefalo. Poster presentato a XLVIII Congresso Nazionale AMCLI 2019, Rimini.
  • Bottino P, Di Vincenzo A, Zanotto E, Balloco C, Callipo A, Frisicale L, Mantelli S, Piasentin AE, Varetto S, Sidoti F, Avolio M, Costa C, Cavallo R. Valutazione di un pannello molecolare multiplex nell’identificazione e quantificazione di patogeni responsabili di infezioni delle basse vie respiratorie. Poster presentato a XLVIII Congresso Nazionale AMCLI 2019, Rimini.
  • Bottino P, Grandi G, Costa C, Cavallo R. valutazione in vitro delle proprietà antisettiche di un collirio contenente poliesanide cloridrato e disodio edetato nei confronti di batteri implicati in infezioni oculari. Poster presentato a XLVIII Congresso Nazionale AMCLI 2019, Rimini.
  • Bondi A, Bottino P, Peradotto M, Zanotto E, Barbui AM, Sidoti F, Cavallo R. Distribuzione dei sierotipi di h.influenzae causanti malattia invasiva nella popolazione piemontese dal 2012 al 2019. Poster presentato a XLVIII Congresso Nazionale AMCLI 2019, Rimini.
  • Bertolini S, Barzanti P, Ru G, Rizzo F, Sparasci O, Braghin S, Moshe D, Bottino P, Sidoti F, Mandola ML. One Health applicata alla clamidiosi in Piemonte: risultati di uno studio cross-sectional per identificare i fattori di rischio per il pollame e l’uomo. Poster presentato a XLIII Congresso Nazionale AIE 2019, Catania.
  • Zanotto E, Abbasciano I, Barreca A, Bottino P, Sidoti F, Costa C, Cavallo R. Retrospective analysis of Polyomavirus BK-associated nephropathy in kidney transplant patients from 2015 to May 2019. Poster presentato a 3rd Congresso Nazionale SIV-ISV 2019, Padova.
  • Rizzo F, Sparasci AO, Braghin S, Boetti E, Olivieri G, Piumetti G, Vaschetti G, Bottino P, Curtoni A, Barzanti P, Vicari N, Mandola ML. Investigation of Chlamydia spp in poultry and humans in Northwest Italy. Poster presentato a 13th Congresso Internazionale EPIZONE 2019, Berlino.
  • Bottino P, Zanotto E, Sidoti F, Balloco C, Varetto S, Callipo A, Mantelli S, Piasentin AE, Costa C, Cavallo R. Cytomegalovirus DNA extraction from dried blood spots: sensibility of two different methods of extraction at 1 month and 1 year from collection of samples. Poster presentato a 29th Congresso Internazionale ECCMID 2019, Amsterdam.
  • Zanotto E, Brossa S, Cipriani R, Bottino P, Varetto S, Callipo A, Balloco C, Mantelli S, Piasentin AE, Sidoti F, Zaccaria T, Barbui A M, Cavallo R. Valutazione dell’analizzatore molecolare BD MAX – BD: confronto con tecniche colturali e molecolari per il rilevamento di patogeni sessuali ed enterici. Poster presentato a XLVII Congresso Nazionale AMCLI 2018, Rimini.
  • Rocchetti A, Gamalero E, Fabio Rapallo, Bottino P. Performance of a new combination of blood culture vials in sepsis detection: a two-year retrospective comparison. Poster presentato a 27th Congresso Internazionale ECCMID 2017, Vienna.
  • Bottino P, Gamalero E, Mazzeo R, Rocchetti A. Valutazione della performance clinica di 3 flaconi per emocoltura BACTEC: plus aerobic/f, plus anaerobic/f e lytic. Poster presentato a XLV Congresso Nazionale AMCLI 2016, Rimini.

 

Congressi e corsi

  • 7th Congress of the European Association of Veterinary Laboratory Diagnosticians, 22 Ottobre 2024, Padova
  • 51° Congresso nazionale AMCLI 2024, della durata di 4 giorni in data 24/03/2024 - 27/04/2024, presso Palacongressi di Rimini, Rimini
  • 34th Congresso Internazionale Congress ECCMID 2024, della durata di 4 giorni in data 27/04/2024 – 30/04/2024, Barcellona
  • 33rd Congresso Internazionale Congress ECCMID 2023, della durata di 4 giorni in data 15/04/2023 – 18/04/2023, Copenhagen
  • 32nd Congresso Internazionale Congress ECCMID 2022, della durata di 4 giorni in data 23/04/2022 - 26/04/2022 (webinar)
  • XLIX Congresso nazionale AMCLI 2022, della durata di 4 giorni in data 26/02/2022 - 01/03/2022, presso Palacongressi di Rimini, Rimini
  • XI Congresso Nazionale SISMEC 2021, della durata di 3 giorni in data 15/09/2021 - 17/09/2021 (webinar)
  • 31th Congresso Internazionale ECCMID 2021, della durata di 4 giorni in data 09/07/2021 - 12/07/2021 (webinar)
  • 5th Congresso Nazionale SIV-ISV 2021, della durata di 2 giorni in data 05/07/2021 - 06/07/2021 (webinar)
  • Virtual Fourth Congress of the Italian Society for Virology, della durata di 1 giorni in data 11/12/2020 (webinar)
  • XXIV Congresso nazionale S.I.TRA.C. 2020, della durata di 3 giorni in data 20/02/2020 - 22/02/2020, presso Centro congressi Stazione Marittima, Napoli
  • Workshop “Hot topics in oftalmologia: rischio infettivo e nutraceutica”, della durata di 1 giorno in data 14/02/2020, presso Villa Malta, Roma
  • XLVIII Congresso nazionale AMCLI 2019, della durata di 4 giorni in data 09/11/2019 - 12/11/2019, presso Palacongressi di Rimini, Rimini
  • 29th Congresso Internazionale ECCMID 2019, della durata di 4 giorni in data 13/04/2019 - 16/04/2019, presso RAI Amsterdam, Amsterdam
  • XLVII Congresso nazionale AMCLI 2018, della durata di 4 giorni in data 10/11/2018 - 13/11/2018, presso Palacongressi di Rimini, Rimini
  • Workshop “Hologic Diagnostic Solutions Forum 2018”, della durata di 2 giorni in data 19/06/2018 - 20/06/2018, presso Hilton Amsterdam Airport Schiphol, Amsterdam.
  • 7th Gut Microbiota For Health World Summit 2018, della durata di 2 giorni in data 10/03/2018 - 11/03/2018, presso Barceló Aran Mantegna Hotel, Roma.
  • Corso “La parassitologia, dalle basi alla pratica diagnostica. Micro-Young-Group: Advancement in Parasitology” della durata di 5 giorni in data 23/10/2017-27/10/2017, presso CREMOPAR (Centro Regionale per il Monitoraggio delle Parassitosi), Eboli.
  • XLV Congresso nazionale AMCLI 2016, della durata di 4 giorni in data 06/11/2016 - 09/11/2016, presso Palacongressi di Rimini, Rimini.

 

 

Comunicazioni orali

  • 7th Congress of the European Association of Veterinary Laboratory Diagnosticians, “Cross-cutting Technology: a supporting answer to the One-Health Paradigm”, presso Fiera di Padova, 22 Ottobre 2024
  • Corso ONB “Le infezioni respiratorie”, presso sede ONB Piemonte, Liguria, Valle d’Aosta, Torino, 16 Ottobre 2024
  • Festival Ambiente e Sostenibilità, Il microbiologo e l’ambiente, Presso AOU “SS Antonio e Biagio e C. Arrigo”, Alessandria, 8 Ottobre 2024
  • Corso FAD “conoscere e gestire il sistema della superficie oculare. Parte II - Antibiotico-resistenza e razionale degli antisettici in oftalmologia”, 23 Maggio 2023
  • 51° Congresso Nazionale AMCLI 2024, “Evolution of intestinal microbiota and role of fecal microbiota transplant for Clostridioides difficile recurrent infection management: a one-year experience in a tertiary regional hospital” presso Rimini, Palacongressi di Rimini, 26 Marzo 2024
  • XLIX Congresso Nazionale AMCLI 2022, “Reconfiguration of a clinical microbiology laboratory in response to COVID-19 emergency: one-year retrospective analysis in a North-West Italian tertiary teaching hospital”, presso Rimini, Palacongressi di Rimini, 28 Febbraio 2022
  • 3 giorni della scienza 2021, “Lo sapevi che il virus…”, Evento FAD Liceo scientifico e delle scienze applicate Sant’Anna di Torino, 29 Marzo 2021
  • XXIV Congresso nazionale S.I.TRA.C. 2020, “Antibiotico resistenza in oftalmologia e razionale d’uso degli antisettici”, presso Napoli, stazione marittima, 21 Febbraio 2020
  • Workshop “Hot topics in oftalmologia: rischio infettivo e nutraceutica”, “Antibiotico resistenza in oftalmologia e razionale d’uso degli antisettici”, presso Roma, Villa Malta, 14 Febbraio 2020
  • XLVIII Congresso Nazionale AMCLI 2019, “valutazione dei test rapidi standard f influenza a/b fia e rsv ag fia (sd biosensor) nella rilevazione di patogeni respiratori”, presso Rimini, Palacongressi di Rimini, 11 Novembre 2019

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