Carlotta Arato
- 502301
- Dottorato: 38° ciclo
- Dipartimento di Scienze Mediche
- Matricola: 807138
Contatti
- carlotta.arato@edu.unito.it
- Laboratorio di Nefrologia e Immunopatologia Renale, Corso Dogliotti 14, Molinette.
- https://dott-fisiopatologia.campusnet.unito.it/do/studenti.pl/Show?807138
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Supervisore
Luigi BianconeCurriculum vitae
Curriculum VitaeTesi di dottorato
ABSTRACT
Background. Transplant glomerulopathy (TG) is the hallmark of chronic antibody-mediated rejection (cAMR) and can occur with or without anti-HLA donor-specific antibodies (DSAs). The role of NK cells has been hypothesized in both conditions, but data are still lacking, with no available experience with urinary NK cells.
Methods. Among the total number of TG patients diagnosed between 01/01/2013 and 31/12/2024, we considered all patients with available urinary NK, stratified for DSA serostatus and semiquantitative NK score.
Urinary NK cells were tested in flow cytometry with anti-CD3 and anti-CD16+56 antibodies and normalized for urinary creatinine excretion.
Conclusion. This study aims to investigate the role of NK cells in patients with TG in particular the correlation between the presence of NK cells in urine and DSA status.
These results suggest that the search for identifiable biomarkers using a non-invasive, reliable and rapid technique, such as flow cytometry, remains a fundamental goal in diagnostics to clarify renal damage, but also to evaluate the therapeutic progress and clinical response to the treatments performed.
Attività di ricerca
ATTENDED PhD CLASSES & COURSES 2°YEAR 2024
07/06 - Pathophysiological basis of diabetic nephropathy, Prof.ssa Gabriella Gruden
14/06 - Pathophysiological and biomarker pathways of cardiovascular emergencies and translational, Prof. Morello
05/07 - Dietary salt: from physiology to disease, Prof.ssa Silvia Monticone
10/07 - Cardiac electric physiopathological properties, Prof. Gaetano De Ferrari
15/07 - Alteration of interstinal microbioma as organ insufficiency: translational implications, Prof. Francesco Giuseppe De Rosa
25/09 - Metabolic syndrome on the digestive tract and translational application, Prof.ssa Elisabetta Bugianesi
ATTENDED PhD CLASSES & COURSES 1° YEAR 2023
APPROACHES TO SCIENTIFIC REASERCH
16/05 - Fitting regression models, Prof.ssa Milena Maule
20/06 - Scientific presentations, Prof.ssa Benedetta Bussolati
11/07 - How to write a scientific paper, Prof.ssa Riccarda Granata
13/07 - How to set up an in vivo experimental model, Prof.ssa Stefania Bruno
PATHOPHYSIOLOGICAL BASIS OF DISEASES
18/05 - Etiopathogenesis of diabetic retinopathy, Prof. Massimo Porta
27/06 - Physiopathology of diabetic nephropathy, Prof.ssa Gabriella Gruden
04/07 - Update on physiology of hypertension, Prof. Franco Veglio
PhD seminar II° year
30/01 - New York Career Day: Opportunities for Italian Researchers
13/04 - Top Design Tips for Publications and Graphical Abstracts
PhD seminar I° year
26/04/2023 - Cardioprotection through pharmacological conditioning, Ioanna Andreadou, University of Athens, Greece
Courses II° year
01/03 - 23/05 - BIBLIOGRAPHY AND BIBLIOMETRICS LIKE PROS: STAY UP TO DATE AND DEVELOP LITERATURE SYNTHESES IN THE BIOMEDICAL DOMAIN
01/03 - Transporting Dangerous Goods Training, ASCLS P.A.C.E., Mayo Clinic Laboratories
November 2024 - Corso Auditor / Lead Auditor Norma ISO 9001:2015 - Qualificato KHC2024 (24h)
10/07 - An introduction to Public Engagement, Unito (2h)
18/07 - Utilizzo in Sicurezza di Gas Compressi e Criogenici e relative attrezzature (4h)
05/08 - ICH GOOD CLINICAL PRACTICE E6 (R2), Global Health Training Centre
May 2024 - Storytelling be strategic in your job and your life, Unito (12h)
E-learning courses I° year
- Variabili Preanalitiche e Medicina di Laboratorio: update 2023 (ancora in corso 10h), SIBioC Medicina di Laboratorio
- Good Clinical Practice for Investigator and Trial Sites Based on ICH E6(R2), A.O.U. Città della Salute e della Scienza di Torino (14h)
- "Lavorare in gruppo nelle organizzazioni", Università degli Studi di Torino
- "Prepararsi alla selezione: dal CV al colloquio di lavoro", Università degli Studi di Torino
- "ICH Good Clinical Practice E6 (R2), The Global Health Network
- General training course on Health and Safety for workers
- Training course on Hygiene and Safety – High Risk in the Health area
Practical courses II° year
- laboratory activities - participation in research studies:
Studio Merck (2022-2023);
Studio Retrophin (2022-2023);
Studio Zenith (September 2024-in progress);
Studio Arctic (October-in progress);
- Activity in the nephrology laboratory (300h)
- Practice lessons in the laboratory for nephrologists (30h)
Practical courses I° year
November 2022- November 2023 - Activity in the nephrology laboratory
- Practice lessons in the laboratory for nephrologists (30h)
Workshop
03/05 - 12/06 Innovation Office Impact Series 2023, Università degli Studi di Torino, Rigas Tehniska Universitate, Ollscoil na Gaillimhe University of Galway, ASTP A World of Knowledge Transfer (7h)
Congresses II° year
June 2024 - Young renal week, SIN Società Italiana Nefrologia
Congresses I° year
4-6/10 Congresso nazionale SIN, Società Italiana Nefrologia, Torino
12-13/05 "Gestione Clinica del Tapianto Renale" Molinette, Torino