Dottorato in Fisiopatologia Medica

Contatti

Supervisore

Curriculum vitae

Attività di ricerca

PROJECT TITLE

Metabolic mechanisms of liver fibrosis progression and non-invasive biomarkers of fibrosis in nonalcoholic fatty liver disease (NAFLD)

ATTENDED PhD CLASSES (2023)

SCIENTIFIC-TEACHING ACTIVITY (November 2022 - October 2023)

 - Member of the European Association for the Study of the Liver (EASL) and of the Italian Association for the Study of the Liver (AISF)

 - 2022 – current: teaching activity (Collaboratore alla Didattica) at the Nursing Degree Course of the Azienda Sanitaria Locale Torino, University of Turin; supporting teaching and tutoring activity at the School of Medicine of the University of Turin 

- Member of the Editorial Board of “Frontiers in Hepatology” as Review Editor

- Reviewer for the following journals: Digestive and Liver Disease, JHep Reports, Liver International, Hepatology 

- 2022 - current: attendance at the University Medical Center of Mainz as member of the Metabolic Liver Research Program led by Prof. Jörn M. Schattenberg. Research activity for PhD project on novel fibrogenesis markers in cooperation with the Institute for Translational Immunology led by Prof. Detlef Schuppan. Conceptualization of experimental protocols for the non-pharmacological treatment of Non-Alcoholic Fatty Liver Disease (NAFLD). Diagnostic and prognostic role of spleen stiffness measurement in chronic compensated advanced liver disease and portal hypertension

- March, 16^th – 17^th 2023: poster presentation at AISF – Annual Meeting (Rome): "Echocardiography-based markers of subclinical cardiac dysfunction in individuals with Non-Alcoholic Fatty Liver Disease and preserved ejection fraction: interim data from a prospective cohort"

- March, 17^th 2023: lecture at the Symposium "Update on Fatty Liver Disease management: beyond 2021 AISF guidelines" of the AISF Annual Meeting (Rome) with a presentation entitled "An update on NASH drug pipeline"

- Turin, May 18^th 2023: presentation entitled "Come sviluppare un progetto di ricerca? Dall'idea alla realizzazione" for the "R4F project" organized by Tutorato di Medicina of the School of Medicine, University of Turin 

- Innovations in NAFLD Care Workshop 2023; oral presentation “Time restricted feeding for the management of Non-Alcoholic Fatty Liver Disease: interim analysis from a randomized, placebo-controlled interventional study”. Barcelona, 27 May 2023

- Vienna, 21^th - 24^th June 2023: poster presentation at EASL ILC 2023 Congress: "Accuracy of 100 Hz transient elastography-based spleen stiffness for the identification of advanced fibrosis in biopsy-proven Non-Alcoholic Fatty Liver Disease.

- Turin, June 16^th 2023: lecture at the Congress "Casi clinici multidisciplinari nelle malattie infiammatorie croniche intestinali: terapie tradizionali e a bersaglio molecolare" with a presentation entitled: "Complicanze epatologiche in IBD"

- Turin, October 3^rd 2023: lecture at the Congress "PBC ed epatopatie autoimmuni ad impronta colestatica" with a lecture entitled: "Prospective validation of LSM in PBC patients"

- Copenhagen, October 14^th - 17^th 2023: Junior Chair at the session "Mechanisms and treatment of steatotic liver" at the UEG Week 2023

- Copenhagen, October 14^th - 17^th 2023: Expert Panel of the Clinical Case Discussion section on Spontaneuos Bacterial Peritonitis

- Verbania, October 20^th 2023: lecture at the Congress "XV incontro piemontese in endocrinologia, diabetologia e metabolismo" with a presentation entitled: "Complicanze epatiche dell'obesità: NAFLD/NASH"

- Award winner of the UEG Research Fellowship 2023 with the project: “Immune activation and the liver-spleen axis in Non-Alcoholic Steatohepatitis”

PUBLICATIONS INDEXED ON PUBMED (November 2022 - October 2023):

- Armandi A, Merizian T, Werner MM, et al. Variability of transient elastography-based spleen stiffness performed at 100 Hz. Eur Radiol Exp 2023; in press.

- Petroni ML, Colosimo S, Brodosi L, Armandi A, Bertini F, Montesi D, Bugianesi E, Marchesini G. Long-term follow-up of web-based and group-based behavioural intervention in NAFLD in a real world clinical setting. Aliment Pharmacol Ther. 2023 Oct 16. 

- Perez-Diaz-Del-Campo N, Dileo E, Castelnuovo G, Nicolosi A, Guariglia M, Caviglia GP, Rosso C, Armandi A, Bugianesi E. A nutrigenetic precision approach for the management of non-alcoholic fatty liver disease. Clin Nutr. 2023 Nov;42(11):2181-2187.

- Castelnuovo G, Perez-Diaz-Del-Campo N, Rosso C, Guariglia M, Armandi A, Nicolosi A, Caviglia GP, Bugianesi E. Impact of Chronotype and Mediterranean Diet on the Risk of Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease. Nutrients. 2023 Jul 23;15(14):3257. 

- Armandi A, Michel M, Gjini K, Emrich T, Bugianesi E, Schattenberg JM. Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease. Expert Rev Mol Diagn. 2023 Jul-Dec;23(9):771-782. 

- Perez-Diaz-Del-Campo N, Castelnuovo G, Rosso C, Nicolosi A, Guariglia M, Dileo E, Armandi A, Caviglia GP, Bugianesi E. Impact of Health Related QoL and Mediterranean Diet on Liver Fibrosis in Patients with NAFLD. Nutrients. 2023 Jul 2;15(13):3018. 

- Mózes FE, Lee JA, Vali Y, Alzoubi O, Staufer K, Trauner M, Paternostro R, Stauber RE, Holleboom AG, van Dijk AM, Mak AL, Boursier J, de Saint Loup M, Shima T, Bugianesi E, Gaia S, Armandi A, Shalimar, Lupșor-Platon M, Wong VW, Li G, Wong GL, Cobbold J, Karlas T, Wiegand J, Sebastiani G, Tsochatzis E, Liguori A, Yoneda M, Nakajima A, Hagström H, Akbari C, Hirooka M, Chan WK, Mahadeva S, Rajaram R, Zheng MH, George J, Eslam M, Petta S, Pennisi G, Viganò M, Ridolfo S, Aithal GP, Palaniyappan N, Lee DH, Ekstedt M, Nasr P, Cassinotto C, de Lédinghen V, Berzigotti A, Mendoza YP, Noureddin M, Truong E, Fournier-Poizat C, Geier A, Martic M, Tuthill T, Anstee QM, Harrison SA, Bossuyt PM, Pavlides M; LITMUS investigators. Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis. Lancet Gastroenterol Hepatol. 2023 Aug;8(8):704-713. 

- Michel M, Labenz C, Armandi A, Kaps L, Kremer WM, Galle PR, Grimm D, Sprinzl M, Schattenberg JM. Metabolic dysfunction-associated fatty liver disease in people living with HIV. Sci Rep. 2023 Jun 6;13(1):9158.

- Rosso C, Caviglia GP, Birolo G, Armandi A, Pennisi G, Pelusi S, Younes R, Liguori A, Perez-Diaz-Del-Campo N, Nicolosi A, Govaere O, Castelnuovo G, Olivero A, Abate ML, Ribaldone DG, Fariselli P, Valenti L, Miele L, Petta S, Romero-Gomez M, Anstee QM, Bugianesi E. Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2023 May 4:S1542-3565(23)00324-5. 

- Canivet CM, Zheng MH, Qadri S, Vonghia L, Chuah KH, Costentin C, George J, Armandi A, Adams LA, Lange NF, Blanchet O, Moal V, Younes R, Roux M, Chan WK, Sturm N, Eslam M, Bugianesi E, Wang Z, Dufour JF, Francque S, Yki-Järvinen H, Zheng KI, Boursier J. Validation of the Blood Test MACK-3 for the Noninvasive Diagnosis of Fibrotic Nonalcoholic Steatohepatitis: An International Study With 1924 Patients. Clin Gastroenterol Hepatol. 2023 Nov;21(12):3097-3106.e10. 

- Armandi A, Bugianesi E. Extrahepatic Outcomes of Nonalcoholic Fatty Liver Disease: Cardiovascular Diseases. Clin Liver Dis. 2023 May;27(2):239-250.

- Armandi A, Caviglia GP, Abdulle A, Rosso C, Gjini K, Castelnuovo G, Guariglia M, Perez Diaz Del Campo N, D'Amato D, Ribaldone DG, Saracco GM, Bugianesi E. Prognostic Value of Simple Non-Invasive Tests for the Risk Stratification of Incident Hepatocellular Carcinoma in Cirrhotic Individuals with Non-Alcoholic Fatty Liver Disease. Cancers (Basel). 2023 Mar 8;15(6):1659. 

- Castelnuovo G, Perez-Diaz-Del-Campo N, Guariglia M, Poggiolini I, Armandi A, Rosso C, Caviglia GP, Bugianesi E. Prebiotics targeting gut-liver axis to treat non-alcoholic fatty liver disease. Minerva Gastroenterol (Torino). 2023 Mar 9. 

- D'Ascenzo F, Bruno F, Iannaccone M, Testa G, De Filippo O, Giannino G, Caviglia GP, Bernstein CN, De Ferrari GM, Bugianesi E, Armandi A, Ribaldone DG. Patients with inflammatory bowel disease are at increased risk of atherothrombotic disease: A systematic review with meta-analysis. Int J Cardiol. 2023 May 1;378:96-104. 

- Ribaldone DG, Vieujean S, Julsgaard M, Armandi A, Zingone F, Savarino E, Cañete F, Aratari A, Imperatore N, Ramos L, Plaza R, Pugliese D, Barberio B, Drobne D, Chaparro M. Non-hepatic Solid Organ Transplant in Patients with Inflammatory Bowel Disease: An ECCO CONFER Multicentre Case Series. J Crohns Colitis. 2023 Jul 5;17(7):1097-1102. 

- Petroni ML, Brodosi L, Armandi A, Marchignoli F, Bugianesi E, Marchesini G. Lifestyle Intervention in NAFLD: Long-Term Diabetes Incidence in Subjects Treated by Web- and Group-Based Programs. Nutrients. 2023 Feb 3;15(3):792. 

- Armandi A, Rosso C, Younes R, Leeming DJ, Karsdal MA, Caviglia GP, Pérez-Diaz-Del-Campo N, D'Amato D, Abdulle A, Nicolosi A, Castelnuovo G, Saracco GM, Ribaldone DG, Bugianesi E. Cross-Sectional and Longitudinal Performance of Non-Invasive Tests of Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease. J Clin Med. 2023 Jan 13;12(2):650. 

- Caviglia GP, Garrone A, Bertolino C, Vanni R, Bretto E, Poshnjari A, Tribocco E, Frara S, Armandi A, Astegiano M, Saracco GM, Bertolusso L, Ribaldone DG. Epidemiology of Inflammatory Bowel Diseases: A Population Study in a Healthcare District of North-West Italy. J Clin Med. 2023 Jan 13;12(2):641. 

- Armandi A, Colombo G, Rosso C, Caviglia GP, Olivero A, Abate ML, Guariglia M, Perez Diaz Del Campo N, Castelnuovo G, Ribaldone DG, Saracco GM, Genazzani AA, Bugianesi E. The Predictive Role of Extracellular NAPRT for the Detection of Advanced Fibrosis in Biopsy-Proven Non-Alcoholic Fatty Liver Disease. Int J Mol Sci. 2023 Jan 7;24(2):1172. 

- Caviglia GP, Abate ML, Troshina G, Carucci P, Rolle E, Risso A, Burlone ME, Albè A, Crevola M, Musso EC, Rosso C, Armandi A, Olivero A, Minisini R, Saracco GM, Bugianesi E, Pirisi M, Ciancio A, Gaia S. Identification of the Best Cut-Off Value of PIVKA-II for the Surveillance of Patients at Risk of Hepatocellular Carcinoma Development. Biology (Basel). 2023 Jan 7;12(1):94

- Perez-Diaz-Del-Campo N, Castelnuovo G, Caviglia GP, Armandi A, Rosso C, Bugianesi E. Role of Circadian Clock on the Pathogenesis and Lifestyle Management in Non-Alcoholic Fatty Liver Disease. Nutrients. 2022 Nov 27;14(23):5053. 

- Rosso C, Demelas C, Agostini G, Abate ML, Vernero M, Caviglia GP, D'Amato D, Armandi A, Tapparo M, Guariglia M, Troshina G, Massano A, Olivero A, Nicolosi A, Zannetti A, Pellicano R, Ciancio A, Saracco GM, Ribaldone DG, Bugianesi E, Fagoonee S. Expression of SARS-Cov-2 Entry Factors in Patients with Chronic Hepatitis. Viruses. 2022 Oct 29;14(11):2397. 

 PARTICIPATION TO NATIONAL AND INTERNATIONAL PROJECTS:

- TESEO (Traguardi di Eccellenza nelle Scienze mediche Esplorando le Omiche) Project - MIUR Dipartimenti di Eccellenza of the Department of Medical Sciences, Unviersity of Torino, under the programme “Dipartimenti di Eccellenza 2018-2022”; Project code D15D18000410001

- LITMUS (Liver Investigation: Testing Marker Utility in Steatohepatitis) and LITMUS Imaging Study; grant agreement No. 777377 (European Union’s Horizon 2020 research and innovation programme)

- Clinical trial “Impact of Time-Restricted Feeding in NAFLD (NAFLD-TRF)”, ClinicalTrials.gov Identifier: NCT05220956

Pubblicazioni