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Dott.ssa Elena Ceccotti

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Curriculum vitae

Curriculum Vitae

Attività di ricerca

Study of the effects of stem cell-derived extracelluar vesicles on the noncoding RNA (ncRNA) expression profile in an in vitro and in vivo model of hepatic fibrosis.

Study of the therapeutic potential of stem cell-derived extracellular vesicles in an in vitro model of hepatic fibrosis and in an in vitro 3D model of hepatic spheroids.

Study of the therapeutic potential of human liver stem cells-derived extracellualar vesicles (HLSC-EVs) in a murine model of IRI-AKI/CKD, 5/6 PNx and hepatic cirrhosis.

Study of the molecular mechanisms at the basis of the regenerative therapeutic potential of stem cell-derived extracellular vesicles.

 

1. Pomatto M, Gai C, Negro F, Cedrino M, Grange C, Ceccotti E , Togliatto G, Collino F, Tapparo M, Figliolini F, Lopatina T, Brizzi MF, Camussi G. Differential Therapeutic Effect of Extracellular Vesicles Derived by Bone Marrow and Adipose Mesenchymal Stem Cells on Wound Healing of Diabetic Ulcers and Correlation to Their Cargoes. Int J Mol Sci. 2021. DOI: https:// doi.org/10.3390/ijms22083851

2. Chiabotto G, Ceccotti E , Tapparo M, Camussi G, Bruno S. Human liver stem cell derived extracellular vesicles target hepatic stellate cells and attenuate their pro fibrotic phenotype. Front. Cell Dev. Biol. 2021. DOI: 10.3389/fcell.2021.777462

3. Bruno S, Chiabotto G, Cedrino M, Ceccotti E , Pasquino C, De Rosa S, Grange C, Tritta S, Camussi G. Extracellular Vesicles Derived from Human Liver Stem Cells Attenuate Chronic Kidney Disease Development in an In Vivo Experimental Model of Renal Ischemia and Reperfusion Injury. Int.J.Mol.Sci.2022. DOI:https://doi.org/10.3390/ijms23031485

 
4. Chiabotto G, Ceccotti E , Bruno S. Narrative review of in vitro experimental models of hepatic fibrogenesis. Digestive Medicine Research. 2022. 
DOI: https://dx.doi.org/10.21037/dmr 21 102
 
5. Ceccotti E , Saccu G, Herrera Sanchez MB, Bruno S. Naïve or Engineered Extracellular Vesicles from Different Cell Sources: Therapeutic Tools for Kidney Diseases. Pharmaceutics. 2023. DOI: https://doi.org/10.3390/ pharmaceutics15061715
 
6. Chiabotto G, Ceccotti E , Pasquino C, Herrera Sanchez MB, Cedrino M, Camussi G, Bruno S. Human liver stem cell derived extracellular vesicles modulate long non coding RNA expression profile in an in vivo model of non alcoholic steatohepatitis. Explor Dig Dis. 2023. DOI: https://doi.org/10.37349/edd.2023.00025

 

1. 20-22 September 2021, Barga (LU): 2nd EVita Symposium - Poster. Abstract title: “Human liver stem cell-derived extracellular vesicles target hepatic stellate cells and attenuate their pro-fibrotic phenotype”

2. 25-29 May 2022, Lyon (France): ISEV 2022 annual meeting - Featured oral presentation and Poster. Abstract title for oral presentation: “Human liver stem cell-derived extracellular vesicles interfere with the development of chronic kidney disease in an in vivo experimental model of renal ischemia and reperfusion injury”. Abstract title for poster: “Human liver stem cell-derived extracellular vesicles improve fibrosis in an in vivo model of non-alcoholic steatohepatitis and modulate lncRNA expression profile”

3.  29-30 September 2022, Torino (TO): 2nd EVIta workshop-fostering collaborations - Oral presentation. Abstract title: “Extracellular vesicles derived from human liver stem cells modulated the expression of epithelial-mesenchymal transition genes in an in vivo experimental model of renal ischemia and reperfusion injury"

4. 20-21 October 2022, Torino (TO): GISM 2022 - Oral presentation and Poster. Abstract title: "Human liver stem cell-derived extracellular vesicles interfere with the development of chronic kidney disease in an in vivo experimental model of renal ischemia and reperfusion injury"

5. 6-10 February 2023, Venezia (VE): XXVII SCHOOL OF PURE AND APPLIED BIOPHYSICS in Extracellular vesicles: from biophysical to translational challenges - Poster. Abstract title: "Anti fibrotic effect of extracellular vesicles derived from human stem cells in an in vitro model of liver fibrosis

6. 17-21 May 2023, Seattle (WA): ISEV 2023 annual meeting - Poster. Abstract title: “Extracellular vesicles derived from human liver stem cells counteract chronic kidney disease development and cardiac dysfunction in remnant kidney murine model

7. 13-15 September 2023, Urbino (PU): 3nd EVita Symposium - Oral presentation. Abstract title:“Extracellular vesicles derived from human liver stem cells counteract Chronic Kidney Disease development and Cardiac Dysfunction in remnant kidney murine model

 

1. 11-13 January 2021, Online Workshop (University of Chile): Extracellular Vesicles in Biomedicine

2. 24-25 March 2021, Online Symposium (Nordic Bioscience): Extracellular Matrix Pharmacology Symposium

3. 29 January 2021, Online Webinar (labroots): Stem cell derived exosome production in stirred-tank bioreactors

4. 12 March 2021 - 9 April 2021 - 14 May 2021 - 11 June 2021, Online Webinar series (Miltenyi Biotec): FloxFix Webinar Series

5. 15-16 February 2023, Online Symposium (ISEV): 2nd Virtual Symposium: Urinary Extracellular Vesicles (uEVs)

6. Online and free available course of BioRender: BioRender 101: Getting Started With BioRender!

1. 18 February 2021, Online training course - University of Torino: Corso di Formazione Generale alla Salute e Sicurezza per i lavoratori (art. 37 del D.Lgs. 81/08) - Certificate of attendance and profit

2. 22 February 2021 - 21 March 2021, Online training course - Doctoral School of the University of Torino: Bibliography and bibliometrics like pros. Stay up to date and Develop Literature Syntheses in the Biomedical Domain - Certificate of attendance

3. 28 March 2021, Online training course - Doctoral School of the University of Torino: Basics of project writing - Certificate of attendance

4. 13 June 2021, Online training course - University of Torino: Corso di formazione in materia di igiene e sicurezza - Rischio alto in area sanitaria - Settore Ateco 2007 Q86 - (D. Lgs. 81/08 s.m.i.) - Certificate of attendance and profit

5. 29 July 2021, Online lecture - University of Torino: Fitting regression models: interpretation of regression coefficients, uncertainty measures and hypothesis testing - Milena Maule

6. 30 August 2021, Online lecture - University of Torino: Physiopathology of diabetic nephropathy - Gabriella Gruden

7. 31 August 2021, Online lecture - University of Torino: Update on physiology of hypertension - Franco Veglio

8. 6 September 2021, Online lecture - University of Torino: Precision medicine in oncology: Putting drivers and targets in context - Livio Trusolino

9. 8 September 2021, in presence lecture - University of Torino: How to write a scientific paper - Riccarda Granata

10. 13 September 2021, Online lecture - University of Torino: Targets for functional imaging in medicine - Desireè Deandreis:

11. 15 Semptember 2021, in presence lecture - University of Torino: Scientific presentations - Benedetta Bussolati

12. 23 September 2021, Online lecture - University of Torino: Regression models: from the linear model to the generalised linear models. Interpretation of interactions between predictors - Milena Maule

13. 28 September 2021, Online lecture - University of Torino: Etiopathogenesis of diabetic retinopathy - Massimo Porta

14. 14 June 2022, in presence lecture- University of Torino: Monogenic forms of hypertension - Paolo Mulatero

15. 1 September 2022, Online lecture- University of Torino: Diabetic nephropathy - Gabriella Gruden/Federica Barutta

16. 13 September 2022, Online lecture- University of Torino: Precision medicine in oncology: putting drivers targets in context - Livio Trusolino

17. 20 September 2022, Online lecture, University of Torino: Cancer survivors: pathophysiology of late-effects and challenges in their management - Emanuela Arvat

18. 1 June 2023, Online lecture, University of Torino: Alteration of intestinal microbioma as organ insufficiency: practical implications - Francesco Giuseppe De Rosa

19. 6 June 2023, Online lecture, University of Torino: Biology and Diagnosis of SARS CoV2 - Cristina Costa

20. 8 June 2023, Online lecture, University of Torino: Cardiac electric physiopathological properties - Gaetano De Ferrari

21. 8 June 2023, Online lecture, University of Torino: Therapeutic strategies for liver transplant - Renato Romagnoli

 

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