Dottorato in Fisiopatologia Medica

2021 - XXXVIII National Congress of the Italian Society of Hypertension (Digital Edition): “Definizione della diagnosi di sottotipo di iperaldosteronismo primitivo in caso di incanulamento di una sola vena surrenalica e soppressione controlaterale al cateterismo” [Poster Presentation], “Sviluppo e validazione di modelli di predizione per la diagnosi di sottotipo in pazienti con iperaldosteronismo primitivo” [Oral Communication], and “Applicazione di algoritmi di supervised e unsupervised learning per stratificare il rischio cardiovascolare secondo una firma molecolare derivata dalla caratterizzazione delle vescicole extracellulari circolanti” [Oral Communication].

2021 - 2nd EVIta Symposium: “Profiling circulating extracellular vesicle surface antigens in primary aldosteronism” [Poster Presentation].

2021 - Seminar on "Alteration of intestinal microbioma as organ insufficiency: a microbiological point of view" (as part of PhD Program).

2021 - Seminar on "Fitting regression models: interpretation of regression coefficients, uncertainty measures and hypothesis testing" (as part of PhD Program).

2021 - Student Network on EVs (SNEV) International Virtual conference: “Serum derived extracellular vesicles are endowed with enhanced procoagulant activity in infection by SARS-CoV-2” [Poster Presentation].

2021 - SPRING Young Investigators Meeting SIIA-SIMI-SIPREC-SISA Virtual Edition: “Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature” [Oral Communication].

2021 - Joint Meeting ESH-ISH 2021 – Global Hypertension Hub - On Air: “Renin-Angiotensin-Aldosterone System Triple-A Analysis for the screening of primary aldosteronism” [Poster Presentation] and “Prevalence of primary aldosteronism and hypokalemia in 5,100 patients referred to a tertiary hypertension unit” [Oral Communication].

2020 – EVIta Workshop on EV-based biomarkers (Webinar - Participation as auditor).

2020 - XXXVII National Congress of the Italian Society of Hypertension (Digital edition): “Triple-A Analysis: un nuovo test di screening per i pazienti con sospetto iperaldosteronismo primitivo attraverso il dosaggio di Aldosterone, Angiotensina I e Angiotensina II” [Poster Presentation].

2020 - A.R.C.A. Young Investigator Awards Meeting: “Circulating extracellular vesicles as biomarkers in patients after ST-segment elevation myocardial infarction” [Oral Communication].

2019 - Design and Analysis of 'omics' studies (Seminar - Participation as auditor).

2019 - 1st EVIta Symposium: “Characterization and gene expression analysis of serum-derived extracellular vesicles in primary aldosteronism” [Poster Presentation] and “Circulating extracellular vesicles as biomarkers in patients after ST-segment elevation myocardial infarction” [Oral Communication].

2019 - 1st Lugano ExoDay - Technical Challenges in Exosome Research: “Profiling circulating extracellular vesicle surface markers as translational diagnostic tool” [Oral Communication] and “Circulating exosomes as a diagnostic tool in ST-segment elevation myocardial infarction” [Poster Presentation].

2019 - D-Day: PhD programmes of the Life Science and Health Area; University of Turin.

2019 - Lecture course of the International PhD Program in Human Cardiovascular Sciences (Faculty of Biomedical Sciences - Univerità della Svizzera Italiana, Lugano Switzerland): Prof. Lionetti V. (Scuola Superiore Sant'Anna, Pisa; 21.02.2019) - Dr.ssa Ghigo A. (University of Turin; 14.03.2019) - Prof. Agnetti G. (Johns Hopkins School of Medicine, Baltimore; 25.04.2019) - Prof. Pedrazzini T. (University of Lausanne; 16.05.2019) - Prof Paolocci N. (Johns Hopkins School of Medicine, Baltimore; 13.06.2019).

2019 - XXXVI National Congress of the Italian Society of Hypertension: “Caratterizzazione e analisi di gene-expression delle vescicole extra-cellulari isolate da siero di pazienti con iperaldosteronismo primitivo” [Oral Communication] and “Sviluppo di uno score per la predizione dell’outcome clinico in pazienti con iperaldosteronismo primitivo dopo surrenectomia monolaterale” [Poster Presentation].

2019 - 29th European Meeting on Hypertension and Cardiovascular Protection, ESH: “Characterization and gene expression analysis of serum-derived extracellular vesicles in primary aldosteronism” [Poster Presentation], and “Pharmacological treatment of arterial hypertension in children and adolescents: a network meta-analysis” [Poster Presentation].

2019 - Joint Annual Meeting 2019 of the Swiss Society of Cardiology and Swiss Society of Cardiac Surgery, SGK: “Circulating exosomes as biomarkers in patients after ST-segment elevation myocardial infarction” [Poster Presentation].

2019 - IX National Congress of Swiss-Italian Research: “Circulating exosomes as a diagnostic tool in ST-segment elevation myocardial infarction” [Poster Presentation].

2018 - Annual PhD presentation day of Doctoral School in Medical Physiopathology (University of Torino).

2018 - XXXV National Congress of the Italian Society of Hypertension: “Studio di network metanalisi sul trattamento farmacologico dell’ipertensione arteriosa in età pediatrica” [Poster Presentation].

2017 - 27th European Meeting on Hypertension and Cardiovascular Protection, ESH: “Prevalence and Clinical Phenotype of Primary Aldosteronism in Primary Care Hypertensives” [Oral presentation in poster area].

2016 - XXXIV National Congress of the Italian Society of Hypertension: “Evoluzione dei noduli surrenalici rilevabili alla TC in pazienti con iperaldosteronismo primitivo bilaterale” [Poster Presentation].

2016 - ESH Summer School of Hypertension in Sirmione, Italy: “Diagnostic accuracy of aldosterone and renin measurement by chemiluminescent immunoassay and radioimmunoassay in primary aldosteronism: the RENATO study” [Poster Presentation].

2015 - XXXIII National Congress of the Italian Society of Hypertension, in the session Best Clinical Case: “Un caso di iperaldosteronismo ed iperkaliemia” [Oral Communication].

2015 - XXXII National Congress of the Italian Society of Hypertension: “Confronto tra le metodiche di misurazione di aldosterone e renina in chemiluminescenza e radio-immuno assay nella diagnosi di iperaldosteronismo” [Poster Presentation].

2015 - 25th European Meeting on Hypertension and Cardiovascular Protection, ESH: “Comparison between Aldosterone and Renin measurement by Chemiluminescent immunoassay and Radioimmunoassay for the Diagnosis of Primary Aldosteronism” [Oral Communication].

2015 - Interregional Congress – Piemonte, Liguria, Valle d’Aosta Section – Italian Society of Hypertension: “Caso Clinico di Iperaldosteronismo con Iperkaliemia” [Oral Communication].

2014 - XXXI National Congress of the Italian Society of Hypertension: “Prevalenza e correlati clinici delle mutazioni di CACNA1D negli adenomi producenti aldosterone” [Oral Communication].

 

Scientific activity

2018-present 

PhD student at University of Torino (Doctoral School of Medical Physiopathology) with a project entitled “Circulating extracellular vesicles as biomarkers in cardiovascular disease”.

2018-2019 

Fellowship at the Laboratory of Molecular and Cellular Cardiology, Departments of Cardiology and Heart Surgery, Cardiocentro Ticino, Lugano (Switzerland) directed by Prof. G. Vassalli and Dr. L. Barile. Research activity focused on the cardioprotective role of extracellular vesicles derived from cardiac progenitor cells and on EV characterization as diagnostic tool for human diseases.

2015-2018     

Fellowship at the Nephrology and Immunology laboratory directed by Prof. G. Camussi (University of Turin); research activity is focused on extracellular vesicles and their potential role in cardiovascular disease.

2010-present 

Clinical research: epidemiology, diagnosis and treatment of secondary forms of hypertension and in particular primary aldosteronism and monogenic forms of low renin hypertension.

2010-present 

Basic research: mechanisms involved in autonomous aldosterone production and cell proliferation in aldosterone producing adenomas; genetic and genomic alterations in sporadic and familial hyperaldosteronism.

 

Clinical activity

August 2013 – July 2018       

Hypertension Outpatient Clinic fellowship at Hypertension Excellence Centre – Division of Internal Medicine (Prof. F. Veglio), University of Torino (TO), Italy

August 2013 – July 2018       

Fellow in Internal Medicine - Division of Internal Medicine (Director, Prof. F. Veglio), Città della Salute e della Scienza di Torino, University of Torino (TO), Italy

April 2017 – September 2017           

Fellow in the Emergency Department (Director, Prof. Lupia), Città della Salute e della Scienza di Torino, University of Torino (TO), Italy

October 2017 – April 2018    

Fellow in the Emergency Department (Director, Prof. Cibinel), Giovanni Agnelli Hospital, Pinerolo (TO), Italy

July 2021 - Present

Clinical Activity as Specialist in Internal Medicine – Division of Internal Medicine (Director, Prof. F. Veglio), Città della Salute e della Scienza di Torino, University of Torino (TO), Italy

 

2018 - Speciality in Internal Medicine, University of Torino, Italy, with a final score of 70/70 cum Laude, honors and publication recommended, for a thesis entitled “Characterization and Gene Expression Analysis of Serum-derived Extracellular Vesicles in Primary Aldosteronism”.

2013 - Italian National Medical Board Exam

2012 - M.D. degree, University of Torino, Torino, Italy, with a final score of 110/110 cum  Laude, honors and publication recommended, for a thesis entitled: “Visinin-Like 1 Is Upregulated in Aldosterone-Producing Adenomas With KCNJ5 Mutations and Protects From Calcium-Induced Apoptosis”, published in Hypertension 2012

2006 - Graduated from Scientific Lyceum (100/100)

 

Publications 2021

1. Buffolo F*, BURRELLO J*, Burrello A*, Heinrich D, Adolf C, Müller LM, Chen R, Forestiero V, Sconfienza E, Tetti M, Veglio F, Williams TA, Mulatero P, Monticone S. “Clinical score and machine learning-based model to predict diagnosis of primary aldosteronism in arterial hypertension”. Hypertension. 2021 August 2 [*contributed equally] [Accepted].
2. BURRELLO J*, Bianco G*, Burrello A, Manno C, Maulucci F, Pileggi M, Nannoni S, Michel P, Bolis S, Melli G, Vassalli G, Albers GW, Cianfoni A, Barile L, Cereda CW. “Extracellular Vesicle Surface Markers as a Diagnostic tool in Transient Ischemic Attacks”. Stroke. 2021 Mar 31 [*contributed equally] The manuscript was commented with an editorial: Herman DM, Doeppner TR, Giebel B. “New Light on the Horizon - Extracellular Vesicles as Diagnostic Tool in Transient Ischemic Attack and Ischemic Stroke”. Stroke. 2021 August 4.
3. BURRELLO J, Tetti M, Forestiero V, Biemmi V, Bolis S, Pomatto MAC, Amongero M, Di Silvestre D, Mauri P, Vassalli G, Camussi G, Williams TA, Mulatero P, Barile L, Monticone S. “Characterization of Circulating Extracellular Vesicle Surface Antigens in Patients With Primary Aldosteronism”. Hypertension. 2021 Jul 26.
4. Buffolo F, Sconfienza E, BURRELLO J, Losano I, Mengozzi G, Priolo G, Avataneo V, D'Avolio A, Veglio F, Rabbia F, Mulatero P, Monticone S. “Assessment of Anti-Hypertensive Drug Adherence by Serial Aldosterone-To-Renin Ratio Measurement”. Front Pharmacol. 2021 May 10;12:668843.
5. Pecori A, Buffolo F, BURRELLO J, Mengozzi G, Rumbolo F, Avataneo V, D'Avolio A, Rabbia F, Bertello C, Veglio F, Mulatero P, Monticone S. “Mineralocorticoid receptor antagonist effect on aldosterone to renin ratio in patients with primary aldosteronism”. J Clin Endocrinol Metab. 2021 May 4:dgab290.
6. Balbi C*, BURRELLO J*, Bolis S*, Lazzarini E, Biemmi V, Pianezzi E, Burrello A, Caporali E, Grazioli LG, Martinetti G, Fusi-Schmidhauser T, Vassalli G, Melli G, Barile L. “Circulating Extracellular Vesicles Are Endowed with Enhanced Procoagulant Activity in SARS-CoV-2 Infection”. EBioMedicine. 2021 May 7;67:103369. [*contributed equally]. The manuscript was commented with an editorial: Whiteside LT. “Procoagulant activity of extracellular vesicles in plasma of patients with SARS-CoV-2 infection”. EBioMedicine. 2021 June 3; 68:103411.
7. Vacchi E*, BURRELLO J*, Burrello A, Bolis S, Monticone S, Barile L, Kaelin-Lang A, Melli G. “Profiling Inflammatory Extracellular Vesicles in Plasma and Cerebrospinal Fluid: An Optimized Diagnostic Model for Parkinson’s Disease”. Biomedicines. 2021 Feb 25;9(3):230. [*contributed equally]
8. Giarraputo A, Barison I, Fedrigo M, BURRELLO J, Castellani C, Tona F, Bottio T, Gerosa G, Barile L, Angelini A. “A Changing Paradigm in Heart Transplantation: An Integrative Approach for Invasive and Non-Invasive Allograft Rejection Monitoring”. Biomolecules. 2021 Feb 1;11(2):201.
9. Albino D, Falcione M, Uboldi V, Temilola DO, Sandrini G, Merulla J, Civenni G, Kokanovic A, Stürchler A, Shinde D, Garofalo M, Mestre RP, Constâncio V, Wium M, BURRELLO J, Baranzini N, Grimaldi A, Theurillat JP, Bossi D, Barile L, Henrique RM, Jeronimo C, Zerbini LF, Catapano CV, Carbone GM. “Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer”. Communic Biol. 2021 Jan 26;4(1):119.
10. BURRELLO J*, Amongero M*, Buffolo F, Sconfienza E, Forestiero V, Burrello A, Adolf C, Handgriff L, Reincke M, Veglio F, Williams TA, Monticone S, Mulatero P. “Development of a prediction score to avoid confirmatory testing in patients with suspected primary aldosteronism”. J Clin Endocrinol Metab. 2021 Mar 25;106(4):e1708-e1716. [*contributed equally].
11. Buffolo F, Cavaglià G, BURRELLO J, Amongero M, Tetti M, Pecori A, Sconfienza E, Veglio F, Mulatero P, Monticone S. “Quality of life in primary aldosteronism: a prospective observational study”. Eur J Clin Investig. 2021 Mar;51(3):e13419.
12. Williams TA, Gomez-Sanchez CE, Rainey WE, Giordano TJ, Lam AK, Marker A, Mete O, Yamazaki Y, Zerbini MCN, Beuschlein F, Satoh F, BURRELLO J, Schneider H, Lenders JWM, Mulatero P, Castellano S, Knösel T, Papotti M, Saeger W, Sasano H, Reincke M. “International histopathology consensus for unilateral primary aldosteronism”. J Clin Endocrinol Metab. 2021 Jan 1;106(1):42-54. 

Publications 2020

1. BURRELLO J*, Burrello A*, Pieroni J, Sconfienza E, Forestiero V, Amongero M, Rossato D, Veglio F, Williams TA, Monticone S, Mulatero P. “Prediction of hyperaldosteronism subtypes when adrenal vein sampling is unilaterally successful”. Eur J Endoc. 2020 September. [*contributed equally].
2. Vohra T, Kemter E, Sun N, Dobenecker B, Hinrichs A, BURRELLO J, Gomez-Sanchez EP, Gomez-Sanchez CE, Wang J, Kinker IS, Teupser D, Fischer K, Schnieke A, Peitzsch M, Eisenhofer G, Walch A, Reincke M, Wolf E, Williams TA. “Effects of dietary sodium modulation on pig adrenal steroidogenesis and gene expression”. Hypertension. 2020 September.
3. BURRELLO J*, Biemmi V*, Dei Cas M*, Amongero M, Bolis S, Lazzarini E, Bollini S, Vassalli G, Paroni R, Barile L. “Sphingolipid composition of circulating extracellular vesicles after myocardial ischemia”. Scientific Report. 2020 Sep 30;10(1):16182. [*contributed equally].
4. Eisenhofer G, Durán C, Cannistraci CV, Peitzsch M, Williams TA, Riester A, BURRELLO J, Buffolo F, Prejbisz A, Beuschlein F, Januszewicz A, Mulatero P, Lenders JWM, Reincke M. “Use of Steroid Profiling Combined with Machine Learning for Identification and Subtype Classification in Primary Aldosteronism”. JAMA Network Open. 2020 Sep 1;3(9):e2016209.
5. Yang Y, Williams TA, Song Y, Yang S, He W, Cheng Q, Ma L, Luo T, Yang J, Reincke M, BURRELLO J, Li Q, Mulatero P, Hu J, the Chongqing Primary Aldosteronism Study (CONPASS) Group. “Nomogram-Based Preoperative Score for Predicting Clinical Outcome in Unilateral Primary Aldosteronism”. J Clin Endocrinol Metab. 2020 Dec 1;105(12):dgaa634.
6. Vacchi E*, BURRELLO J*, Di Silvestre D, Burrello A, Bolis S, Mauri P, Vassalli G, Cereda CW, Farina C, Barile L, Kaelin-Lang A, Melli G. “Immune profiling of plasma-derived extracellular vesicles identifies Parkinson’s disease”. Neurol Neuroimmunol Neuroinflamm. 2020 Aug 12;7(6):e866. [*contributed equally].
7. Williams TA, Gomez-Sanchez CE, Rainey WE, Giordano TJ, Lam AK, Marker A, Mete O, Yamazaki Y, Zerbini MCN, Beuschlein F, Satoh F, BURRELLO J, Schneider H, Lenders JWM, Mulatero P, Castellano S, Knösel T, Papotti M, Saeger W, Sasano H, Reincke M. “International histopathology consensus for unilateral primary aldosteronism”. J Clin Endocrinol Metab. 2020 Jul 27:dgaa484. 
8. BURRELLO J*, Burrello A*, Pieroni J, Sconfienza E, Forestiero V, Rabbia P, Adolf C, Reincke M, Veglio F, Williams TA, Monticone S, Mulatero P. “Development and validation of prediction models for subtype diagnosis of patients with primary aldosteronism”. J Clin Metab Endocrinol 2020 Oct 1;105(10):dgaa379. [*contributed equally].
9. Castellani C*, BURRELLO J*, Fedrigo M, Burrello A, Bolis S, Di Silvestre D, Tona F, Bottio T, Biemmi V, Toscano G, Gerosa G, Thiene G, Basso C, Longnus SL, Vassalli G, Angelini A, Barile L. “Circulating Extracellular Vesicles as a Noninvasive Biomarker of Rejection in Heart Transplant”. J Heart Lung Transplant 2020 Jun 20. pii: S1053-2498(20)31610-7 [*contributed equally].
10. BURRELLO J, Bolis S, Balbi C, Burrello A, Provasi E, Elena Caporali E, Gauthier LG, Peirone A, D’Ascenzo F, Monticone S, Barile L, Vassalli G. “An extracellular vesicle epitope profile is associated with acute myocardial infarction”. J Cell Mol Med. 2020 Jul 14;24(17):9945-57. [Epub ahead of print]
11. Mulatero P, BURRELLO J, Williams TA, Monticone S. “Primary aldosteronism in the elderly”. J Clin Endocrinol Metab. 2020 Jul;105(7):dgaa206.
12. Biemmi V, Milano G, Ciullo A, Cervio E, BURRELLO J, Dei Cas M, Paroni R, Tallone T, Moccetti T, Pedrazzini G, Longnus S, Vassalli G, Barile L. “Inflammatory extracellular vesicles prompt heart dysfunction via TLR4-dependent NF-kB activation”. Theranostics 2020 Feb; 10(6):2773-2790.
13. BURRELLO J, Monticone S, Losano I, Cavaglià G, Buffolo F, Tetti M, Covella M, Rabbia F, Veglio F, Pasini B, Williams TA, Mulatero P. “Prevalence of Hypokalemia and Primary Aldosteronism in 5,100 patients referred to a tertiary hypertension unit”. Hypertension. 2020 Apr;75(4):1025-1033.
14. BURRELLO J, Buffolo F, Domenig O, Tetti M, Pecori A, Monticone S, Poglitsch M, Mulatero P. “Renin-angiotensin-aldosterone system triple-A analysis for the screening of primary aldosteronism”. Hypertension 2020 Jan;75(1):163-172.
15. Parasiliti-Caprino M, Lucatello B, Lopez C, BURRELLO J, Francesca Maletta, Migliore E, Tassone F, La Grotta A, Reimondo GM, Giordano R, Giraudo G, Piovesan A, Ciccone G, Deandreis D, Limone P, Orlandi F, Borretta G, Volante M, Mulatero P, Papotti M, Aimaretti G, Terzolo M, Morino M, Pasini B, Veglio F, Ghigo E, Arvat E, Maccario M. “Predictors of recurrence of pheochromocytoma and paraganglioma: a multicenter study in Piedmont (northern Italy)”. Hypertens Res. 2020 Jun;43(6):500-510.

Publications 2019

1. Williams TA, Jaquin D, BURRELLO J, Philippe A, Yang Y, Rank P, Nirschl N, Sturm L, Hübener C, Dragun D, Bidlingmaier M, Beuschlein F, Reincke M. “Diverse responses of autoantibodies to the angiotensin II type 1 receptor in primary aldosteronism”. Hypertension. 2019 [Epub ahead of print]. The manuscript was commented with an editorial: Armanini D, Sabbadin C, Bordin L. “Enigma of the Origin of Primary Aldosteronism”. Hypertension. 2019 Oct;74(4):745-746.
2. BURRELLO J, Gai C, Tetti M, Lopatina T, Deregibus MC, Veglio F, Mulatero P, Camussi G, Monticone S. “Characterization and gene expression analysis of serum-derived extracellular vesicles in primary aldosteronism”. Hypertension. 2019 Aug;74(2):359-367. The manuscript was commented with an editorial: Neves KB, Touyz RM. “Extracellular Vesicles as Biomarkers and Biovectors in Primary Aldosteronism”. Hypertension. 2019 Aug;74(2):250-252.
3. Vallelonga F, Romagnolo A, Merola A, Sobrero G, Di Stefano C, Milazzo V, BURRELLO J, Burrello A, Zibetti M, Milan A, Veglio F, Maule S. “Detection of orthostatic hypotension with ambulatory blood pressure monitoring in parkinson’s disease” Hypertens Res. 2019 Oct;42(10):1552-1560.
4. Vallelonga F, Di Stefano C, Merola A, Romagnolo A, Sobrero G, Milazzo V, Burrello A, BURRELLO J, Zibetti M, Veglio F, Maule S. “Blood pressure circadian rhythm alterations in alpha-synucleinopathies”. J Neurol. 2019 May;266(5):1141-1152.
5. BURRELLO J*, Burrello A*, Stowasser M, Nishikawa T, Quinkler M, Prejbisz A, Lenders JWM, Satoh F, Mulatero P, Reincke M, Williams TA. “The Primary Aldosteronism Surgical Outcome Score for the Prediction of Clinical Outcomes After Adrenalectomy for Unilateral Primary Aldosteronism”. Ann Surg. 2019 Jan 18 [*contributed equally]. [Epub ahead of print].
6. Yang Y*, BURRELLO J*, Burrello A, Eisenhofer G, Peitzsch M, Tetti M, Knösel T, Beuschlein F, Lenders JW, Mulatero P, Reincke M, Williams TA. “Classification of microadenomas in patients with primary aldosteronism by steroid profiling”. J Steroid Biochem Mol Biol. 2019 May;189:274-282. [*contributed equally].
7. Pappaccogli M, Di Monaco S, Perlo E, BURRELLO J, D’Ascenzo F, Veglio F, Monticone S, Rabbia F. “Comparison of Automated Office Blood Pressure With Office and Out-Off-Office Measurement Techniques. A Systematic Review and Meta-Analysis”. Hypertension. 2019 Feb;73(2):481-490.

Publications 2018

1. Meyer LS, Wang X, Sušnik E, BURRELLO J, Burrello A, Castellano I, Eisenhofer G, Fallo F, Kline GA, Knösel T, Kocjan R, Lenders JWM, Mulatero P, Naruse M, Nishikawa T, Peitzsch M, Rump LC, Beuschlein F, Hahner S, Gomez-Sanchez CE, Reincke M, Williams TA. “Immunohistopathology and Steroid Profiles Associated With Biochemical Outcomes After Adrenalectomy for Unilateral Primary Aldosteronism”. 2018 Sep;72(3):650-657.
2. Williams TA, BURRELLO J, Sechi LA, Fardella CE, Matrozova J, Adolf C, Baudrand R, Bernardi S, Beuschlein F, Catena C, Doumas M, Fallo F, Giacchetti G, Heinrich DA, Saint-Hilary G, Jansen PM, Januszewicz A, Kocjan T, Nishikawa T, Quinkler M, Satoh F, Umakoshi H, Widimský Jr J, Hahner S, Douma S, Stowasser M, Mulatero P, Reincke M. “Computed Tomography and Adrenal Venous Sampling in the Diagnosis of Unilateral Primary Aldosteronism”. Hypertension. 2018 Sep;72(3):641-649.
3. Avataneo V, De Nicolò A, Rabbia F, Perlo E, BURRELLO J, Berra E, Pappaccogli M, Cusato J, D'Avolio A, Di Perri G, Veglio F. “Therapeutic drug monitoring guided definition of adherence profiles in resistant hypertension and identification of predictors of poor adherence”. Br J Clin Pharmacol. 2018 Nov;84(11):2535-2543.
4. BURRELLO J*, Erhardt EM*, Saint-Hilary G, Veglio F, Rabbia F, Mulatero P, Monticone S, D’Ascenzo F. “Pharmacological Treatment of Arterial Hypertension in Children and Adolescents. A Network Meta-Analysis”. 2018 Aug;72(2):306-313 [*contributed equally].
5. Pappaccogli M, Covella M, Berra E, Fulcheri C, Di Monaco S, Perlo E, BURRELLO J, Monticone S, Rossato D, Rabbia F, Veglio F. “Effectiveness of Renal Denervation in Resistant Hypertension: A Meta-Analysis of 11 Controlled Studies”. High Blood Press Cardiovasc Prev. 2018 May 11.
6. Tetti M, Monticone S, BURRELLO J, Matarazzo P, Veglio F, Pasini B, Jeunemaitre X, Mulatero P. “Liddle Syndrome: Review of the Literature and Description of a New Case”. Int J Mol Sci. 2018 Mar 11;19(3). pii: E812.

Publications 2017

1. Buffolo F, Monticone S, BURRELLO J, Tetti M, Veglio F, Williams TA, Mulatero P. “Is Primary Aldosteronism Still Largely Unrecognized?”. Horm Metab Res 2017; Dec;49(12):908-914.
2. Prada ETA, BURRELLO J, Reincke M, Williams TA. “Old and New Concepts in the Molecular Pathogenesis of Primary Aldosteronism”. 2017; Nov;70(5):875-881.
3. Williams TA, Lenders JWM, Mulatero P, BURRELLO J, Rottenkolber M, Adolf C, Satoh F, Amar L, Quinkler M, Deinum J, Beuschlein F, Kitamoto KK, Pham U, Morimoto R, Umakoshi H, Prejbisz A, Kocjan T, Naruse M, Stowasser M, Nishikawa T, Young Jr WF, Gomez-Sanchez CE, Funder JW, Reincke M. The Primary Aldosteronism Surgery Outcome (PASO) investigators “Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort”. The Lancet. 2017; Sep;5(9):689-699.
4. Viola A, Monticone S, Rossato D, Versace K, Castellano I, BURRELLO J, Buffolo F, Veglio F, Mulatero P. “A Case of Adrenal Vein Sampling in Primary Aldosteronism With Homolateral Suppression”. J Endo Soc. 2017; Mar 17;1(5):401-406.
5. BURRELLO J, Monticone S, Buffolo F, Tetti M, Veglio F, Williams TA, Mulatero P. “Is There a Role for Genomics in the Management of Hypertension?”. Int J Mol Sci 2017; May 26;18(6). pii: E1131.
6. Monticone S, Tetti M, BURRELLO J, Buffolo F, De Giovanni R, Veglio F, Williams TA, Mulatero P. “Familial hyperaldosteronism type III”. J Hum Hyperten 2017; Dec;31(12):776-781.
7. Buffolo F, Monticone S, Williams TA, Rossato D, BURRELLO J, Tetti M, Veglio F, Mulatero P. “Subtype Diagnosis of Primary Aldosteronism: Is Adrenal Vein Sampling Always Necessary?”. Int J Mol Sci 2017. Apr 17;18(4). pii: E848.
8. Monticone S*, BURRELLO J*, Tizzani D, Bertello C, Viola A, Buffolo F, Gabetti L, Mengozzi G, Williams T.A, Rabbia, F, Veglio F, Mulatero P. “Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice”. J Am Coll Cardiol 2017; Apr 11;69(14):1811-1820 [*contributed equally].

Publications 2016

1. Mulatero P, Monticone S, BURRELLO J, Veglio F, Williams TA, Funder J. “Guidelines for primary aldosteronism: uptake by primary care physicians in Europe”. J Hypertens 2016; Nov;34(11):2253-7.
2. BURRELLO J, Monticone S, Gai C, Gomez Y, Kholia S, Camussi G. “Stem Cell-Derived Extracellular Vesicles and Immune-Modulation”. Front Cell Dev Biol 2016; Aug 22;4:83.
3. Crudo V, Monticone S, BURRELLO J, Buffolo F, Tetti M, Veglio F, Mulatero P. “Hyperaldosteronism: How to Discriminate Among Different Disease Forms?”. High Blood Press Cardiovasc Prev 2016; Sep;23(3):203-8.
4. BURRELLO J, Monticone S, Buffolo F, Lucchiari M, Tetti M, Rabbia F, Mengozzi G, Williams T.A, Veglio F, Mulatero P. “Diagnostic accuracy of aldosterone and renin measurement by chemiluminescent immunoassay and radioimmunoassay in primary aldosteronism”. J Hypertens 2016; May;34(5):920-7.

Publications 2015

1. Mulatero P, BURRELLO J, Lucatello B, Giacchetti G, Battocchio M, Fallo F. “Evolution of computer tomography-detectable adrenal nodules in patients with bilateral primary aldosteronism”. Endocrine 2015; Dec;54(3):826-829.
2. BURRELLO J, Monticone S, Tetti M, Rossato D, Versace K, Castellano I, Williams TA, Veglio F, Mulatero P. “Subtype Diagnosis of Primary Aldosteronism: Approach to Different Clinical Scenarios”. Horm Metab Res 2015; Dec;47(13):959-66.
3. Williams TA, Lenders JWM, BURRELLO J, Beuschlein F, Reincke M. “KCNJ5 Mutations: Sex, Salt and Selection”. Horm Metab Res 2015; Dec;47(13):953-8.
4. Williams TA, Dietz A, Theodoropoulou M, Riester A, Fischer E, BURRELLO J, Treitl M, Geyer L, Veglio F, Bidlingmaier M, Schopohl J, Beuschlein F, Mulatero P, Reincke M. “Co-existing prolactinoma and primary aldosteronism - is there a pathophysiological link?”. J Clin Endocrinol Metab 2015; Sep;100(9):E1262-9.
5. Viola A,Monticone S, BURRELLO J, Buffolo F, Lucchiari M, Rabbia F, Williams TA, Veglio F, Mengozzi G, Mulatero P. “Renin and aldosterone measurements in the management of arterial hypertension”. Horm Metab Res. 2015 Jun;47(6):418-26.
6. Grillo A, Bernardi S, Rebellato A, Fabris B, Bardelli M, BURRELLO J, Rabbia F, Veglio F, Fallo F, Carretta R. “Ambulatory Blood Pressure Monitoring-Derived Short-Term Blood Pressure Variability in Primary Aldosteronism”. J of Clin Hyperten 2015; Aug;17(8):603-8.
7. BURRELLO J,Monticone S, Buffolo F, Tetti M, Giraudo G, Schiavone D, Veglio F, Mulatero P. “Issues in the Diagnosis and Treatment of Primary Aldosteronism”. High Blood Press Cardiovasc Prev. 2015; Jun;23(2):73-82.

Publications 2014

1. Monticone S, Satoh F, Viola A, Fischer E, Vonend O, Bernini G, Lucatello B, Quinkler M, Ronconi V, Morimoto R, Kudo M, Degenhart C, Gao X, Carrara D, Willenberg HS, Rossato D, Mengozzi G, Riester A, Paci E, Iwakura Y, BURRELLO J, Maccario M, Giacchetti G, Veglio F, Ito S, Reincke M, Mulatero P. “Aldosterone suppression on contralateral adrenal during adrenal vein sampling does not predict blood pressure response after adrenalectomy”. J Clin Endocrinol Metab. 2014 Nov;99(11):4158-66.
2. Williams TA, Monticone S, Schack VR, Stindl J, BURRELLO J, Buffolo F, Annaratone L, Castellano I, Beuschlein F, Reincke M, Lucatello B, Ronconi V, Fallo F, Bernini G, Maccario M, Giacchetti G, Veglio F, Warth R, Vilsen B, Mulatero P. “Somatic ATP1A1, ATP2B3, and KCNJ5 Mutations in Aldosterone-Producing Adenomas”. Hypertension. 2014 Jan;63(1):188-95.

Publications 2013

1. Mulatero P, Monticone S, Bertello C, Viola A, Tizzani D, Iannaccone A, Crudo V, BURRELLO J, Milan A, Rabbia F, Veglio F. “Long-term cardio- and cerebrovascular events in patients with primary aldosteronism”. J Clin Endocrinol Metab. 2013 Dec;98(12):4826-33.
2. Viola A, Tizzani D, Monticone S, Crudo V, Galmozzi M, BURRELLO J, Versace K, Loiacono M, Veglio F, Mulatero P. “Diagnosis and treatment of unilateral forms of primary aldosteronism”. Curr Hypertens Rev. 2013 May;9(2):156-65.

Publications 2012

1. Verhovez A, Williams TA, Monticone S, Crudo V, BURRELLO J, Galmozzi M, Covella M, Veglio F, Mulatero P. “Genomic and non-genomic effects of aldosterone”. Curr Signal Transd T. 2012; 7:132-41.
2. Monticone S, Viola A, Tizzani D, Crudo V, BURRELLO J, Galmozzi M, Veglio F, Mulatero P. “Primary Aldosteronism: Who Should be Screened?”. Horm Metab Res. 2012; Mar;44(3):163-9.

Book Chapters: 

Mulatero P, Williams TA, Monticone S, Viola A, Tizzani D, Crudo V, BURRELLO J, Veglio F. “Primary aldosteronism: progress in diagnosis, therapy, and genetics”. C.A. Koch and G.P. Chrousos (eds.), Endocrine Hypertension: Underlying Mechanisms and Therapy, Contemporary Endocrinology, DOI 10.1007/978-1-60761-548-41.

 

Awards and honors

2021 - F4LabMed - De Barjac prize for the publication “Immune profiling of plasma-derived extracellular vesicles identifies Parkinson disease”, published in Neurology Neuroimmunology & Neuroinflammation.

2021 - SIIA 2021 “Alberto Zanchetti” Best Publication Award for the paper “Prevalence of Hypokalemia and Primary Aldosteronism in 5100 Patients Referred to a Tertiary Hypertension Unit”, published in Hypertension.

2021 - Best Oral Communication at the SPRING Young Investigators Meeting (Joined SIIA-SIMI-SIPREC-SISA Societies) for the project: “Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature”.

2020 - Selected among the 10 best applicants for the A.R.C.A. Young Investigator Awards for the project “Circulating extracellular vesicles as biomarkers in patients after ST-segment elevation myocardial infarction”.

2019 - Young Investigator Award, of the joined Italian- and British-Irish Hypertension Societies (SIIA-BIHS) for the project: “Characterization and gene expression analysis of serum-derived extracellular vesicles in primary aldosteronism”.

2016 - Selected to attend 2016 Summer School of Hypertension, in Sirmione (Italy).

2015 - Best Clinical Case Award at the XXXII National Congress of the Italian Society of Hypertension for the oral communication: “Un caso di iperaldosteronismo ed iperkaliemia”.

2013 - Distinguished Thesis Award, of the Italian Society of Hypertension for the thesis entitled: “Visinin-Like 1 Is Upregulated in Aldosterone-Producing Adenomas With KCNJ5 Mutations and Protects From Calcium-Induced Apoptosis”.

 

National and International collaborations

Germany: Ludwig-Maximilians-University, University Hospital Würzburg, Campus Mitte; Munich.

Switzerland: Cellular and Molecular Cardiology Laboratory, Cardiocentro Ticino Foundation and Swiss Institute for Regenerative Medicine; Lugano.

Switzerland: Laboratory for Cardiovascular Theranostics, Cardiocentro Ticino Foundation; Lugano.

Switzerland: Laboratory for Biomedical Neurosciences, Neurocenter of Southern Switzerland, Ente Ospedaliero Cantonale; Lugano.

Switzerland: Neurology Clinic and Stroke Centre, Ente Ospedaliero Cantonale; Lugano.

Austria: Attoquant Diagnostics GmbH Laboratory; Vienna.

Italy: Polytechnic University, Department of Mathematical Sciences G. L. Lagrange; Torino.

Italy: Department of Electrical, Electronic and Information Engineering Guglielmo Marconi (DEI), University of Bologna.

Italy: Proteomic and Metabolomic Laboratory, Institute for Biomedical Technologies, National Research Council (ITB-CNR), Segrate (Milan).

Italy: Cardiovascular Pathology and Pathological Anatomy Unit, Department of Cardiac, Thoracic, and Vascular Sciences and Public Health; University of Padua.

 

Funding

PRIN 2015 – 201572SHXJ – Sector: ERC LS3. Regenerative potential of extracellular vesicles derived from mesenchymal stem cells on epithelial wound healing. Period: 2017-2020 (Role: Collaborator).

Ex-60% - University of Torino Research Grant – Sector: MED09. Circulating microRNAs carried by Extracellular Vesicles in patients with Primary Aldosteronism. Period: 2019 (Role: Collaborator).

Ex-60% - University of Torino Research Grant – Sector: MED09. Urinary extracellular vesicles as biomarkers of renal allograft dysfunction. Period: 2020 (Role: Collaborator).

The Michael J. Fox Foundation for Parkinson’s Research - Fall 2020 RFA: Parkinson's Pathway Biomarkers. MJFF Grant ID: MJFF-000965. Multiplexed immune-phenotyping of plasma-derived extracellular vesicles as biomarker for early Parkinson’s disease. Period: 2021-2022 (Role: Collaborator).

 

Other

Member of the Editorial Board of Biomedicines [IF 4.7] (2020-2021).

Member of the Italian Society of Hypertension (SIIA) (2013-to date).

Member of the European Society of Hypertension (ESH) (2016-to-2019).

Member of the Italian Society for Extracellular vesicles (EVIta) (2019-to date).

Referee of the following international journals: Hypertension; Stem Cell Reviews and Reports; Frontiers in Oncology; Biomedicines; International Journal of Molecular Science; Journal of the American Heart Association; Journal of Cellular and Molecular Medicine; Cells; Vaccines; Scientific Reports; Endocrine Practice; Frontiers in Endocrinology; Frontiers in Medicine; Surgery; Journal of Endocrinological Investigation; Clinical Endocrinology; Journal of Clinical Medicine; Bioengineered; Endocrine; International Journal of Cardiology; Clinical Epidemiology; Hormone and Metabolic Research; Journal of the Neurological Sciences; International Journal of Endocrinology; Experimental and Clinical Endocrinology & Diabetes; BMC Endocrine Disorders; Diagnostic and Interventional Radiology; Medicina; International Journal of Hypertension; High Blood Pressure and Cardiovascular Prevention.