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Ilaria Goitre

Tesi di dottorato

Title of the PhD project

"Pilot study to evaluate the effects of an innovative dairy product enriched with
bioactive compounds derived from milk on the health status of patients with
gestational diabetes".
 
My research activity
I collaborated with Dairy Inalpi company and I supported the research team to create a low-sugar, high-protein, white yogurt enriched with Lactoferrin.  Our work started from the choice of milk, the type of lactic ferment and the amount of lactoferrin to be added to the yogurt, by assessing the available literature and the recommendations of the European Food Safety Authority. In particular, as a nutritionist, I collaborate to define the nutritional and qualitative properties of the yogurt, determining the appropriate final amount of sugars, fats and proteins. I followed the entire production process, from the arrival of the milk to the final definition of the yogurt for the study, including the step of ultrafiltration of the milk, thanks to which the protein part of the milk, called retentate, was obtained. The retentate was then used to enrich our yogurt with proteins.
We formulated two recipes of the yogurt, one yogurt derived from high-quality cow's milk enriched with lactoferrin during the manufacturing process and the same yogurt, but without Lactoferrin; Both yogurts have the same color, flavor, and texture.
Afterwards, I drafted the study protocol; I submitted this study to the hospital ethics committee in October 2022 and I'm now waiting for their approval in order to start the trial. This will be the work for the next two years of my PhD.
 
 

Attività di ricerca

Research activity, Jen 2022 - Jul 2022: research and development of the product (Yogurt), object of my PhD project. 

 

Lectures 2022

Approaches to scientific research (22 hours)

June 28, 2022 - Precision medicine in oncology: putting drivers and targets in context – Prof. Livio Trusolino

June 30, 2022 - How to write a scientific paper – Prof. Riccarda Granata

July 07, 2022 - How to set up an in vivo experimental model – Prof. Stefania Bruno

July 12, 2022 - Fitting regression models: interpretation of regression coefficients, uncertainty measures and hypothesis testing - Prof. Milena Maule

July 19, 2022 - Regression models: from the linear model to the generalised linear models. Interpretation of interactions between predictors - Prof. Milena Maule

September 27, 2022 - Scientific presentations – Prof. Benedetta Bussolati

Pathophysiological basis of diseases (20 hours)

July 05, 2022 - Update on physiology of hypertension – Prof. Franco Veglio

June 21, 2022 - Etiopathogenesis of diabetic retinopathy – Prof. Massimo Porta

September 6, 2022 - Physiopathology of diabetic nephropathy – Prof. Gabriella Gruden

September 8, 2022 - Targets for functional imaging in medicine – Prof. Désirée Deandreis

September 15, 2022 - Physiopathology of autoimmune hepatitis – Prof. Marilena Durazzo *Rescheduled

 

Publications

Cancello R, Rey F, Carelli S, Cattaldo S, Fontana JM, Goitre I, Ponzo V, Merlo FD, Zuccotti G, Bertoli S, Capodaglio P, Bo S, Brunani A. Telomere Length and Mitochondrial DNA Copy Number Variations in Patients with Obesity: Effect of Diet-Induced Weight Loss-A Pilot Study. Nutrients. 2022 Oct 14;14(20):4293. doi: 10.3390/nu14204293.

 

Ferrocino I, Pellegrini M, D'Eusebio C, Goitre I, Ponzo V, Fadda M, Rosato R, Mengozzi G, Beccuti G, Merlo FD, Rahimi F, Comazzi I, Cocolin L, Ghigo E, Bo S. The Effects of Time-Restricted Eating on Metabolism and Gut Microbiota: A Real-Life Study. Nutrients. 2022 Jun 21;14(13):2569. doi: 10.3390/nu14132569.

 

Ferrocino I, Ponzo V, Pellegrini M, Goitre I, Papurello M, Franciosa I, D'Eusebio C, Ghigo E, Cocolin L, Bo S. Mycobiota composition and changes across pregnancy in patients with gestational diabetes mellitus (GDM). Sci Rep. 2022 Jun 2;12(1):9192. doi: 10.1038/s41598-022-13438-0.

 

Marzola E, Abbate-Daga G, Scumaci E, Ponzo V, Goitre I, Pellegrini M, D'Eusebio C, Benso A, Belcastro S, De Michieli F, Crespi C, Broglio F, Ghigo E, Bo S. In Patients with Obesity, Are Affective Temperaments Associated with Attrition? An Evaluation during and before the SARS-CoV-2 Pandemic. J Clin Med. 2022 Feb 7;11(3):862. doi: 10.3390/jcm11030862.

 

Courses

Oct 2022 Corso di formazione in materia di Igiene e Sicurezza - Rischio Alto in area sanitaria - Settore Ateco 2007 Q 86 - (D. Lgs. 81/08 s.m.i.). - Certificate of attendance.

Corso Fad (SINU e ASAND) - Utilizzo dei database di cmposizione degli alimenti per la valutazione a carattere nutrizionale. - Scheduled for Nov 2022.

 

Congress 2022

Jun 2022 Training event :"Lifestyle medicine: nuovi approcci interdisciplinari per curare la depressione". - Certificate of attendance. 

Jun 2022 Congress: L'educazione alimentare come strumento di prevenzione in tutte le età. Turin. - Certificate of attendance.

Sep 2022 Congress: "L'obesità: un puzzle complesso..focus su alcuni tasselli del puzzle". Turin. - Certificate of attendance.

Congress: "4° International Congress on prevention over 50; dal cibo alle diete: per un invecchiamento in salute." - Scheduled for Nov 2022.

 

Participation to Projects

Participation to the clinical trial: “Non-allergyc non-celiac wheat hypersensitivity: randomized controlled trial of intervention with probiotics. Department of Medical Sciences - University of Turin. - in progress. 

Participation to study "SELECT codice EX9536-4388": "Effects of semaglutide on cardiovascular outcomes in obese or overweight people". Department of Medical Sciences - University of Turin - Novo Nordisk Company. In progress. 

 

 

 

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