Dottorato in Fisiopatologia Medica

Contatti

Supervisore

Tesi di dottorato

PROJECT

“Pathophysiological and diagnostic evaluation of andrological and endo-gynaecological conditions through innovative analytical methods investigating androgen milieu”

Attività di ricerca

During my PhD Course, I have attended a visiting period abroad at Ghent University (Ghent, Belgium), from the 02nd of April to the 3rd of October 2024. I have joined clinical and research activities in andrology, gender incongruence and steroid hormones analyses through LC MS/MS.

ATTENDED PhD CLASSES & COURSES

2022

Approaches to scientific research

June 28, 2022 - Precision medicine in oncology: putting drivers and targets in context – Prof. Livio Trusolino

June 30, 2022 - How to write a scientific paper – Prof.ssa Riccarda Granata

July 07, 2022 - How to set up an in vivo experimental model – Prof.ssa Stefania Bruno

July 12, 2022 - Fitting regression models: interpretation of regression coefficients, uncertainty measures and hypothesis testing - Prof.ssa Milena Maule

July 19, 2022 - Regression models: from the linear model to the generalised linear models. Interpretation of interactions between predictors - Prof.ssa Milena Maule

September 27, 2022 - Scientific presentations – Prof.ssa Benedetta Bussolati

Pathophysiological basis of diseases

July 05, 2022 - Update on physiology of hypertension – Prof. Franco Veglio

June 21, 2022 - Etiopathogenesis of diabetic retinopathy – Prof. Massimo Porta

September 6, 2022 - Physiopathology of diabetic nephropathy – Prof.ssa Gabriella Gruden

September 8, 2022 - Targets for functional imaging in medicine – Prof.ssa Désirée Deandreis

E-learning courses

01/06/2022 – 23/09/2022 Bibliography and bibliometrics like pros. Stay up to date and Develop Literature Syntheses in the Biomedical Domain (14h) - Link: https://elearning.unito.it/strutture_universitarie/course/view.php?id=1321

31/10/2022 – Nature Masterclasses: Focus on Peer Review (3h30) - Link: https://masterclasses.nature.com/focus-on-peer-review-online-course/16605550

2023

2024

May 27-28-29th University of Torino: Summarising evidence from multiple studies - Prof. Aurelio Tobias, Visiting Professor, Spanish Council for Scientific Research, Spain, host: Prof. Milena Maule, Department of Medical Science, University of Torino

May 24th, on line lecture - University of Torino: Pathophysiology of cardiovascular hemodynamics and translational application - Alberto Milan

May 21st, in presence lecture - University of Torino: Cancer survivors. Pathophysiology of late-effects and implication for transaltional application - Emanuela Arvat

July 3rd Genetic Forms of Hypertension - Paolo Mulatero

Transferable skills seminars attended during visiting period at Gent University:

- 27th May - 03rd June 2024 How to deal with media and journalists as a researcher https://www.ugent.be/doctoralschool/en/doctoraltraining/courses/transferableskills/dealing-with-media-and-journalists.htm
- 21st August-04th September 2024: Applying for a post-PhD job https://www.ugent.be/doctoralschool/en/doctoraltraining/courses/transferableskills/applying-for-a-post-phd-job.htm

SCIENTIFIC PUBLICATIONS

2022

• Marinelli L, Beccuti G, Zavattaro M, Cagnina S, Gesmundo I, Bona C, Lopez C, Scabini S, Canta F, Mornese Pinna S, Lupia T, Di Bisceglie C, Ponzetto F, Settanni F, De Rosa FG, Ghigo E, Motta G. Testosterone as a Biomarker of Adverse Clinical Outcomes in SARS-CoV-2 Pneumonia. Biomedicines. 2022 Mar 31;10(4):820. doi: 10.3390/biomedicines10040820. PMID: 35453570; PMCID: PMC9025790.
• Egalini F, Marinelli L, Rossi M, Motta G, Prencipe N, Rossetto Giaccherino R, Pagano L, Grottoli S, Giordano R. Endocrine disrupting chemicals: effects on pituitary, thyroid and adrenal glands. 2022 May 23. doi: 10.1007/s12020-022-03076-x. Epub ahead of print. PMID: 35604630.
• Ponzetto F, Parasiliti-Caprino M, Gesmundo I, Marinelli L, Nonnato A, Nicoli R, Kuuranne T, Mengozzi G, Ghigo E, Settanni F. Single-run UHPLC-MS/MS method for simultaneous quantification of endogenous steroids and their phase II metabolites in serum for anti-doping purposes. Talanta. 2023 Apr 1;255:124218. doi: 10.1016/j.talanta.2022.124218. Epub 2022 Dec 28. PMID: 36603442.

2023

• Marinelli L, Cagnina S, Bichiri A, Magistri D, Crespi C, Motta G. Sexual function of transgender assigned female at birth seeking gender affirming care: a narrative review. Int J Impot Res. 2023 May 5. doi: 10.1038/s41443-023-00711-7. Epub ahead of print. PMID: 37147482.
• Prencipe N, Marinelli L, Varaldo E, Cuboni D, Berton AM, Bioletto F, Bona C, Gasco V, Grottoli S. Isolated anterior pituitary dysfunction in adulthood. Front Endocrinol (Lausanne). 2023 Mar 8;14:1100007. doi: 10.3389/fendo.2023.1100007. PMID: 36967769; PMCID: PMC10032221.
• Felicetti F, Gatti F, Faraci D, Rosso D, Zavattaro M, Fortunati N, Marinelli L, Leone S, Gill J, Dionisi-Vici M, Dellacasa C, Busca A, Giaccone L, Arvat E, Bruno B, Brignardello E. Impact of allogeneic stem cell transplantation on thyroid function. J Endocrinol Invest. 2023 Mar 8. doi: 10.1007/s40618-023-02039-x. Epub ahead of print. PMID: 36884196.
• Lanfranco, F., Marinelli, L., Nieschlag, E. (2023). Klinefelter Syndrome. In: Nieschlag, E., Behre, H.M., Kliesch, S., Nieschlag, S. (eds) Andrology. Springer, Cham. https://doi.org/10.1007/978-3-031-31574-9_21
• Giannelli, J., Campioni, L., Rossi, M., Prencipe, N., Marinelli, L., Pagano, L., & Giordano, R. (2023). Distruttori endocrini dal 2023 in poi. L'Endocrinologo, 24(5), 490-497
• Santi D, Spaggiari G, Marinelli L, Cacciani M, Scipio S, Bichiri A, Profeta A, Granata ARM, Simoni M, Lanfranco F, Manieri C, Ghigo E, Motta G. Gender-affirming hormone treatment: friend or foe? Long-term follow-up of 755 transgender people. J Endocrinol Invest. 2024 May;47(5):1091-1100. doi: 10.1007/s40618-023-02220-2. Epub 2023 Oct 27. PMID: 37889433.

2024

• Ponzetto F, Parasiliti-Caprino M, Leoni L, Marinelli L, Nonnato A, Nicoli R, Kuuranne T, Ghigo E, Mengozzi G, Settanni F. LC-MS/MS measurement of endogenous steroid hormones and phase II metabolites in blood volumetric absorptive microsampling (VAMS) for doping control purposes. Clin Chim Acta. 2024 Apr 15;557:117890. doi: 10.1016/j.cca.2024.117890. Epub 2024 Mar 25. PMID: 38537673.
• Marinelli, L., Bichiri, A., Cagnina, S., Castella, L., Ghigo, E., & Motta, G. (2024). Efficacy of topical minoxidil in enhancing beard growth in a group of transgender assigned female at birth individuals on gender affirming hormone therapy. Journal of Endocrinological Investigation, 1-8.
• Marconi M, Pagano MT, Ristori J, Bonadonna S, Pivonello R, Meriggiola MC, Motta G, Lombardo F, Mosconi M, Oppo A, Cocchetti C, Romani A, Federici S, Bruno L, Verde N, Lami A, Crespi CM, Marinelli L, Giordani L, Matarrese P, Ruocco A, Santangelo C, Contoli B, Masocco M, Minardi V, Chiarotti F, Fisher AD, Pierdominici M. Sociodemographic profile, health-related behaviours and experiences of healthcare access in Italian transgender and gender diverse adult population. J Endocrinol Invest. 2024 Nov;47(11):2851-2864.
• Marinelli, L., Cagnina, S., Bichiri, A., Castella, L., Ledda, F., Di Bisceglie, C., & Motta, G. (2024). Trattamento con le onde d’urto nella disfunzione erettile. L'Endocrinologo, 1-8.
• Tienforti D*, Marinelli L*, Vervalcke J, Spagnolo L, Antolini F, Bichiri A, Baroni MG, Motta G, T'Sjoen G, Barbonetti A. Short-Term Changes in Bone Metabolism Among Transgender Men Starting Gender-Affirming Hormone Therapy: A Systematic Review and Meta-analysis. Calcif Tissue Int. 2024 Oct 2. doi: 10.1007/s00223-024-01296-z. Epub ahead of print. PMID: 39356296.
• Vervalcke J.*, Marinelli L.*, Botte M., Flamant T.,T’Sjoen G. Dose Reduction of Cyproterone Acetate in Trans Women and the Effect on Patient-reported Outcomes: Results from the ENIGI Study Submitted to International Journal of Transgender Health

*=shared first co-authorship

SCIENTIFIC ACTIVITIES:

- Review Editor for "Frontiers in Endocrinology" (IF: 3.9, Citescore: 5.3), reproductive section.

- Tutor for final dissertation thesis for Students of Medicine and Surgery, University of Turin:

2023: "Cardiovascular risk assessment in transgender people undergoing gender-affirming therapy: a literature review and analysis of a multicenter cohort of adult transgender patients"

2023: "Assessment of bone health in a cohort of people with gender incongruence"

2024: "Gender Incongruence in Childhood: Analysis of the Effects of GnRH Analogues in a Cohort of Adolescents"

Family Doctor Specialist 

2023: "Investigation on the access of transgender population to primary care"

- 2023-2024: Part of the Scientific Secretary of the 2nd level master in "Andrology, Reproductive Endocrinology, and Sexual Medicine" - UNITO Coordinator Prof. Ezio Ghigo

PRESENTATION OF PAPERS, POSTERS, GIVEN SPEECHES AT CONFERENCES

• 17-19/02/2022 Poster presentation: “Alterations in thyroid function and female sexual health: effect of restoration of euthyroidism” Virtual Congress of European Society of Sexual Medicine (ESSM)
• 24/05/2022 Oral communication: “Analysis of cardiovascular comorbidities and events in a cohort of transgender people during GAHT” European Congress of Endocrinology (ECE) (Milan, Italy)
• 28/06 – 01/07/22: European Professional Association for Transgender Health (EPATH) Summer School (Doctoral School of Ghent) and Research project presentation: “Refine cardiovascular risk assessment in transgender population” (Ghent, Belgium)
• 17/07 – 20/07/22: European Society of Endocrinology (ESE) Summer School and presentation: “Short and long-term evaluations of hypothalamic-pituitary-gonadal axis in men affected by SARS-CoV-2 pneumonia” (Innsbruck, Austria)

• 04/09/2022 Conference Speech at IIEM National Congress: Proper assumption of contraceptive pill (Naples, Italy)
• 09/09/2022 Italian Society of Endocrinology (SIE) –Piedmont area- Congress of Endocrinology (Cuneo, Italy) Oral Presentation: "From EP to ED: Andrological Issues in Young Men"
  
• 26-28/04/2023 5th Epath Congress (Killarney, Ireland) - Oral presentation:"Analysis of cardiovascular comorbidities and events in a cohort of transgender people during GAHT".
• 13/05/2023 1st SIGIS Congress  (Florence, Italy) - Oral presentation:"Glycemic risk of GAHT" 
  
• 29/09/2023 Italian Society of Endocrinology (SIE) –Piedmont area- Congress of Endocrinology (Cuneo, Italy) Oral presentation ""Contraception and Perimenopause: A Practical Guide"
  
• 18-20/01/2024 XVth SIAMS National Congress (Rome, Italy) - Poster presentation "Testosterone allergy in a transgender AFAB: a case report"
  
• 8-10/02/2024 European Congress ESSM (Bari, Italy) - Oral communication "Short and long-term efficacy of minoxidil on beard growth in a group of assigned female at birth transgender people on gender affirming hormone therapy"
  
• 6-8/09/2024 European Society of Endocrinology (ESE) Young Endocrinologists and Scientists 2024 annual meeting (Helsinki, Finland) - Poster presentation " Short-Term Changes in Bone Metabolism Among Transgender Men Starting Gender-Affirming Hormone Therapy: A Systematic Review and Meta-analysis"
• 26-30/09/2024 28th International Congress of WPATH (Lisbon, Portugal) - Oral communication "Short and Long Term Efficacy of Minoxidil on Beard Growth in A Group of Assigned Female at Birth Transgender Individuals on Gender-Affirming Hormone Therapy"
  
• 04/10/2024 Couple's (In)fertility: Delving Deeper and Providing Care (Novara, Italy) Oral presentation: "Semen Analysis - the WHO 2021 Guidelines"
  

Awards:

• EPATH Summer School grant (28/06 – 01/07/22)
• ESE Summer school grant (17/07 – 20/07/22)

ACTIVE PARTICIPATION TO SCIENTIFIC ASSOCIATIONS ACTIVITIES

Member of:

• European Society of Endocrinology (ESE) and EYES (Young subgroup)
• WPATH (World Professional Association for Transgender Health) and EPATH (European Professional Association for Transgender Health)
• SIE (Italian Society of Endocrinology)
• SIAMS (Italian Society of Andrology and Sexual Medicine) and Androyoung (Young SIAMS Member-Supervisor)
• SID (Italian Society of Diabetology) and YOSID (Young SID Member)
• AME (Association of Medical Doctors in Endocrinology)

Activities:

• Scientific Commette for National Androyoung (Young Italian Andrologist) Congress 2025